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Titolo:
DELETERIOUS BACKGROUND SELECTION WITH RECOMBINATION
Autore:
HUDSON RR; KAPLAN NL;
Indirizzi:
UNIV CALIF IRVINE,DEPT ECOL & EVOLUTIONARY BIOL IRVINE CA 92717 NIEHS,STAT & BIOMATH BRANCH RES TRIANGLE PK NC 27709
Titolo Testata:
Genetics
fascicolo: 4, volume: 141, anno: 1995,
pagine: 1605 - 1617
SICI:
0016-6731(1995)141:4<1605:DBSWR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-MELANOGASTER; DNA POLYMORPHISM; GENETIC HITCHHIKING; CENTROMERIC REGION; X-CHROMOSOME; POPULATIONS; MUTATIONS; EVOLUTION; ANANASSAE; SIMULANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Hudson e N.L. Kaplan, "DELETERIOUS BACKGROUND SELECTION WITH RECOMBINATION", Genetics, 141(4), 1995, pp. 1605-1617

Abstract

An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have beenobserved at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model.

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Documento generato il 02/12/20 alle ore 17:59:23