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Titolo:
INTERACTION OF CYTOKINES WITH CELLULAR RECEPTORS
Autore:
DANILKOVICH AV; DZANTIEV BB;
Indirizzi:
MOSCOW MV LOMONOSOV STATE UNIV,SCH BIOL,DEPT CELL PHYSIOL & IMMUNOL MOSCOW 119899 RUSSIA RUSSIAN ACAD SCI,BAKH INST BIOCHEM,IMMUNOBIOCHEM LAB MOSCOW 117071 RUSSIA
Titolo Testata:
Biochemistry
fascicolo: 9, volume: 60, anno: 1995,
pagine: 1051 - 1060
SICI:
0006-2979(1995)60:9<1051:IOCWCR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; HUMAN GROWTH-HORMONE; MURINE INTERLEUKIN-2 RECEPTOR; LYMPHOCYTE MATURATION FACTOR; ACTIVATED HUMAN LYMPHOBLASTS; HUMAN IL-2 RECEPTOR; GAMMA-CHAIN; SIGNAL-TRANSDUCTION; CRYSTAL-STRUCTURE;
Keywords:
CYTOKINE; RECEPTOR; INTERACTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Danilkovich e B.B. Dzantiev, "INTERACTION OF CYTOKINES WITH CELLULAR RECEPTORS", Biochemistry, 60(9), 1995, pp. 1051-1060

Abstract

The cytokine family comprises biologically active polypeptides which are secreted by cells of the hematopoietic and immune systems and regulate cell proliferation and differentiation. Cytokine binding to specific receptors on the cell surface leads to oligomerization of the receptor. Receptor oligomerization is essential for the biological activity of the cytokines. The cytokine-induced receptor oligomerization is due to a polyvalent cytokine-receptor interaction. Study of the oligomerization mechanism is important for understanding the molecular mechanism of cytokine action and for development of synthetic agonists and antagonists of the cytokine receptors. This article reviews the mechanism of cytokine-receptor interaction that leads to the receptor oligomerization. It is concluded that the polyvalent cytokine-receptor interaction is important for initiation of the oligomerization and for-subsequent formation of the active receptor complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:44:38