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Titolo:
HYPOPHYSITIS IN SURGICAL AND AUTOPTICAL SPECIMENS
Autore:
SAUTNER D; SAEGER W; LUDECKE DK; JANSEN V; PUCHNER MJA;
Indirizzi:
MARIEN HOSP,DEPT PATHOL,ALFREDSTR 9 D-22087 HAMBURG GERMANY MARIEN HOSP,DEPT PATHOL D-22087 HAMBURG GERMANY UNIV HOSP EPPENDORF,NEUROSURG CLIN HAMBURG GERMANY GEN HOSP ST GEORG,DEPT PATHOL HAMBURG GERMANY
Titolo Testata:
Acta Neuropathologica
fascicolo: 6, volume: 90, anno: 1995,
pagine: 637 - 644
SICI:
0001-6322(1995)90:6<637:HISAAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATHKES CLEFT CYST; LYMPHOCYTIC HYPOPHYSITIS; GRANULOMATOUS HYPOPHYSITIS; PITUITARY ABSCESS; ADENOHYPOPHYSITIS; INTRASELLAR; HYPOPITUITARISM; PREGNANCY;
Keywords:
HYPOPHYSITIS; PITUITARY ABSCESS; PITUITARY TUMOR; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
D. Sautner et al., "HYPOPHYSITIS IN SURGICAL AND AUTOPTICAL SPECIMENS", Acta Neuropathologica, 90(6), 1995, pp. 637-644

Abstract

We present the clinical and histological findings of Il cases of inflammatory anterior pituitary lesions, 8 of which were obtained during surgery and 3 of which were obtained from autopsies. Additionally, we extended the conventional classification of pituitary inflammatory disease by the new entity ''secondary hypophysitis''. Of the surgically obtained specimens 5 consisted of inflammatory extension into the pituitary gland out of the surrounding tissue. In all of these patients the inflammation originated from an additional tumor in the sellar region (4 craniopharyngiomas, 1 prolactinoma). These will be referred to as ''secondary hypophysitis''. an entity which has not yet been mentioned in the literature. Of the remaining 6 cases, 2 were granulomatous hypophysitis, 2 pituitary abscesses, 1 lymphocytic hypophysitis, and 1 showed extensive scarring of the anterior pituitary lobe due to preceeding lymphocytic hypophysitis. At histological examination the basic structure of the anterior pituitary was maintained in all cases. Relative counts of hormone-producing cells were normal. In secondary hypophysitis, the affected area was composed of fibrous tissue and granulation tissue. B and T lymphocytes were present in equal amounts. Granulomas were not found. Inflammatory infiltrates, granulation tissue and fibroses were seen in different proportions. Based on our results and three other cases reported in the literature so far, we think that the presently used classification of pituitary inflammatory diseases lacks an entity which describes a non-abscess-forming inflammation of the pituitary gland originating from an associated pathological process. Therefore, we introduced the term secondary hypophysitis to describe this fourth entity of pituitary inflammatory disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:19:41