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Titolo:
THORN-SHAPED ASTROCYTES - POSSIBLY SECONDARILY INDUCED TAU-POSITIVE GLIAL FIBRILLARY TANGLES
Autore:
IKEDA K; AKIYAMA H; KONDO H; HAGA C; TANNO E; TOKUDA T; IKEDA S;
Indirizzi:
SHINSHU UNIV,SCH MED,DEPT MED NEUROL MATSUMOTO NAGANO 390 JAPAN
Titolo Testata:
Acta Neuropathologica
fascicolo: 6, volume: 90, anno: 1995,
pagine: 620 - 625
SICI:
0001-6322(1995)90:6<620:TA-PSI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; NEUROFIBRILLARY CHANGES; ALZHEIMERS-DISEASE; DEMENTIA; BRAINS;
Keywords:
THORN-SHAPED ASTROCYTE; GLIAL FIBRILLARY TANGLES; TAU; ASTROCYTE; STRAIGHT TUBULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Ikeda et al., "THORN-SHAPED ASTROCYTES - POSSIBLY SECONDARILY INDUCED TAU-POSITIVE GLIAL FIBRILLARY TANGLES", Acta Neuropathologica, 90(6), 1995, pp. 620-625

Abstract

Argyrophilic and tau-positive abnormal structures occurring in glial cells are called glial fibrillary tangles. In the astrocyte, a conspicuous tau-positive structure is known to appear in progressive supranuclear palsy (PSP), In this report, another type of argyrophilic and tau-positive astrocytes is reported. The morphology of this new type is quite different from that of the previously reported tau-positive astrocyte in PSP and they are designated here as them-shaped astrocytes (TSA). TSA have an apparently argyrophilic cytoplasm with a few short processes and often have a small eccentric nucleus, whose appearance resembles that of a reactive astrocyte. Immunohistochemically, TSA are positive to anti-tau antibodies but are negative for ubiquitin. Simultaneous immunostaining revealed the coexistence of tau and glial fibrillary acidic protein epitopes in the same cytoplasm, Electron microscopically, bundles of 15-nm straight tubules were included in the cytoplasm together with abundant glial filaments. In the vicinity of a cluster of TSA, related structures of perivascular or subpial tau-positive linings, which correspond to astrocytic end-feet, are sometimes observed. In almost all cases, a few TSA are generally located in a confined area of subpial and subependymal regions. Although TSA appear to be intimately associated with some diseases, they are also found in a wide range of cytoskeletal disorders including the aged brain with neurofibrillary tangles. TSA are presumed to be a secondarily induced product in relation to astrocytic reaction.

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Documento generato il 07/07/20 alle ore 14:45:38