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Titolo:
STUDY ON THE ACCELERATION IN HEALING OF ETHANOL-INDUCED GASTRIC-LESIONS IN RATS BY METHYLPREDNISOLONE
Autore:
GOTO H; SUGIYAMA S; KUROIWA M; OHARA A; HOSHINO H; HAMAJIMA E; KANAMORI S; TSUKAMOTO Y; OZAWA T;
Indirizzi:
NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,FAC MED,DEPT INTERNAL MED NAGOYA AICHI JAPAN
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 2, volume: 44-1, anno: 1994,
pagine: 141 - 145
SICI:
0004-4172(1994)44-1:2<141:SOTAIH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL INJURY; PROSTAGLANDIN-D2; ULCERS; ACID; LEUKOTRIENES; PREVENTION; GENESIS;
Keywords:
CAS 2375-03-3; GASTRIC ULCERS, EXPERIMENTAL; METHYLPREDNISOLONE, PHARMACOLOGY; STEROID HORMONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H. Goto et al., "STUDY ON THE ACCELERATION IN HEALING OF ETHANOL-INDUCED GASTRIC-LESIONS IN RATS BY METHYLPREDNISOLONE", Arzneimittel-Forschung, 44-1(2), 1994, pp. 141-145

Abstract

This study was designed to determine rite influences of methylprednisolone (MP, CAS 2375-03-3) on the genesis and healing of gastric lesions induced by 50% ethanol in relation to tile changes in gastric mucosal prostaglandin (PG) and leukotriene (LT) contents and vascular permeability. Intragastric administration of 1 ml of 50% ethanol induced hemorrhagic lesions in the fundic portion, and these lesions were not affected by 20 mg/ kg of MP injected subcutaneously 30 min before ethanoladministration. In untreated rats, 4 kinds of PGs, i.e., 6-keto-PGF(1a), PGF(2a), PGE(2), and PGD(2), were determined in gastric mucosa by high performance liquid chromatography (HPLC), but no LTs were detected. Administration of ethnnol significantly reduced all PG contents andincreased production of peptide-LTs in gastric mucosa. Pretreatment with MP did not influence ethanol-induced changes in PG and peptide-LT contents. Ethanol-induced lesions required 96 h for total healing. Ulcer healing was not affected by MP, which was injected subcutaneously twice daily from 1 h after ethanol administration until the end ofthe experiment, and complete ulcer healing was observed after 72 h. MP did not affect ethanol-induced decrease in PG contents their recoveries, or peptide-LT contents. Ethanol increased vascular permeability and MP reduced this increase. These results suggest that MP does not have a hazardous effect, but is rather beneficial with regard to healing of ethanol-induced gastric lesions through prevention of the increase in vascular permeability caused by ethanol, and that it affected neither gastric mucosal PG nor peptide-LT contents.

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Documento generato il 30/05/20 alle ore 14:49:31