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Titolo:
ENHANCED RADIOIMMUNOTARGETING OF I-125 LABELED L6-BIOTIN MONOCLONAL-ANTIBODY (MAB) BY COMBINING PRELOAD OF COLD L6 MAB AND SUBSEQUENT IMMUNOADSORPTION IN RATS
Autore:
GARKAVIJ M; TENNVALL J; STRAND SE; NORRGREN K; LINDGREN L; NILSSON R; SJOGREN HO;
Indirizzi:
UNIV LUND HOSP,DEPT ONCOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT RADIAT PHYS S-22185 LUND SWEDEN LUND UNIV,DEPT TUMOR IMMUNOL S-22007 LUND SWEDEN
Titolo Testata:
Cancer research
fascicolo: 23, volume: 55, anno: 1995, supplemento:, S
pagine: 5874 - 5880
SICI:
0008-5472(1995)55:23<5874:EROILL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL LYMPHOMA; EXTRACORPOREAL IMMUNOADSORPTION; RADIOLABELED ANTIBODY; TUMOR UPTAKE; NUDE-MICE; XENOGRAFTS; RADIOIMMUNOTHERAPY; BLOOD; PRETREATMENT; BIOTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Garkavij et al., "ENHANCED RADIOIMMUNOTARGETING OF I-125 LABELED L6-BIOTIN MONOCLONAL-ANTIBODY (MAB) BY COMBINING PRELOAD OF COLD L6 MAB AND SUBSEQUENT IMMUNOADSORPTION IN RATS", Cancer research, 55(23), 1995, pp. 5874-5880

Abstract

The present study investigates whether tumor:normal tissue uptake ratios of radiolabeled monoclonal antibodies can be further improved by acombination of extracorporeal immunoadsorption (ECIA) and preload with unlabeled idiotypic monoclonal antibody. Athymic rats, heterotransplanted with human lung carcinoma under the kidney capsule (SR tumor) and i.m. (IM tumor), were divided into four study groups: controls, ECIA, preload, and combined preload+ECIA. The preload+ECIA procedure reduced the whole-body and plasma activity by 48 and 89%, respectively. After such combined procedure, the uptake of I-125-labeled L6-biotin in SR tumors was unchanged, while the uptake in normal tissues was considerably reduced, Tumor (T):bone marrow ratio was then increased by 17.5 times (after ECIA) and by 4.5 times (24 h after ECIA). Similar enhancements were achieved for T:liver and T:kidney ratios, For the IM tumors, the ratios were not as high as for SR tumors, The effects on T:normal ratios of preload+ECIA in combination were synergistic, The combinedprocedure resulted both in an increased uptake and prolonged persistence of I-125-labeled L6-biotin in the SR tumors and also in a reduction of corresponding uptake values in organs critical for radiation.

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Documento generato il 25/01/21 alle ore 15:35:24