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Titolo:
PHARMACOLOGICAL ACTION OF ZOTEPINE AND OTHER ANTIPSYCHOTICS ON CENTRAL 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPES
Autore:
CZYRAK A; SKUZA G; ROGOZ Z; FRANKIEWICZ T; MAJ J;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,12 SMETNA ST PL-31343 KRAKOW POLAND
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 2, volume: 44-1, anno: 1994,
pagine: 113 - 118
SICI:
0004-4172(1994)44-1:2<113:PAOZAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; SEROTONIN 5-HT1A; SCHIZOPHRENIA; BINDING; POTENT; DRUGS; SITES; TRIFLUOROMETHYLPHENYLPIPERAZINE; CHLOROPHENYLPIPERAZINE; CLASSIFICATION;
Keywords:
ANTIPSYCHOTICS, ATYPICAL; CAS 26615-21-4; 5-HYDROXYTRYPTAMINE, RECEPTOR SUBTYPES; ZOTEPINE, PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Czyrak et al., "PHARMACOLOGICAL ACTION OF ZOTEPINE AND OTHER ANTIPSYCHOTICS ON CENTRAL 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPES", Arzneimittel-Forschung, 44-1(2), 1994, pp. 113-118

Abstract

The effect of the atypical neuroleptic zotepine (CAS 26615-21-4), in comparison with clozapine, risperidone and haloperidol, on the responsiveness of different 5-hydroxytryptamine (5-HT1) receptor subtypes to their agonists was examined in rats and mice. The above antipsychoticswere investigated in the following behavioural tests: 8-OH-DPAT (8-hydroxy-dipropylaminotetralin)- induced behavioural syndrome in rats, mCPP (m- chlorophenylpiperazine)-induced hypothermia in mice and mCPP-induced hypoactivity measured in the open field in rats. Zotepine, clozapine and haloperidol did not affect the behavioural syndrome induced by 8-OH-DPAT (the selective agonist of 5-HT1A, receptor), only risperidone (used in higher doses) attenuated the effect of 8-OH-DPAT. The mCPP-induced hypothermia in mice (a 5-HT1B effect) was affected by neither zotepine nor clozapine, risperidone and haloperidol, all of them used in low doses which did not influence per se the body temperature of mice. All the tested antipsychotics given at high doses induced hypothermia in control mice; at the same time zotepine, clozapine and risperidone attenuated the hypothermic effect of mCPP. mCPP decreases the exploratory activity of rats, this effect being considered to be mediated by 5-HT1C receptors. The tested antipsychotics, used in low doses influenced neither the exploratory activity nor the hypoactivity inducedby mCPP. When used at higher doses they induced hypoactivity in control rats, the hypoactivity after joint administration of zotepine, risperidone or haloperidol and mCPP was significantly greater than after mCPP alone, whereas clozapine slightly attenuated the effect of mCPP. The obtained results indicate that zotepine did not affect the responsiveness of 5-HT1A, and 5-HT1C receptors, but had a slight inhibitory effect on 5-HT1B receptors; the latter effect was shared by clozapine and risperidone, but not haloperidol. Risperidone showed a weak antagonistic effect on 5-HT1A receptors, and clozapine - on 5-HT1C ones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:39:07