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Titolo:
BINDING OF EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-1 TO DNA - INHIBITION BY DISTAMYCIN AND 2 NOVEL DISTAMYCIN ANALOGS
Autore:
FERIOTTO G; CIUCCI A; MISCHIATI C; ANIMATI F; LOMBARDI P; GIACOMINI P; ARCAMONE F; GAMBARI R;
Indirizzi:
UNIV FERRARA,IST CHIM BIOL,VIA L BORSARI 46 I-44100 FERRARA ITALY UNIV FERRARA,IST CHIM BIOL I-44100 FERRARA ITALY MENARINI SUD POMEZIA ITALY IST REGINA ELENA,IMMUNOL LAB I-00161 ROME ITALY UNIV FERRARA,CTR INTERDIPARTIMENTALE BIOTECHNOL I-44100 FERRARA ITALY
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 2, volume: 267, anno: 1994,
pagine: 143 - 149
SICI:
0922-4106(1994)267:2<143:BOENAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR RECOGNITION; PROTEIN INTERACTIONS; SEQUENCE; AMIDINOPHENOXYNEOPENTANE; PURIFICATION; LEXITROPSINS; DESIGN; AGENTS; GENOME; TAPP;
Keywords:
DNA-BINDING DRUG; TRANSCRIPTION FACTOR; EPSTEIN-BARR VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G. Feriotto et al., "BINDING OF EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-1 TO DNA - INHIBITION BY DISTAMYCIN AND 2 NOVEL DISTAMYCIN ANALOGS", European journal of pharmacology. Molecular pharmacology section, 267(2), 1994, pp. 143-149

Abstract

Modulation of the interaction between cellular or viral transcriptionfactors and target DNA sequences may represent a potential experimental strategy to control proliferation of neoplastic cells as well as virus DNA replication. Distamycin represents a likely candidate to mediate such modulation by pharmacological means. In order to obtain more detailed information on structure-activity relationships of these compounds, we have analysed the effects of distamycin and two distamycin analogues on the binding of a recombinant protein, the Epstein-Barr virus nuclear antigen 1 (EBNA-1) to its target sequence of Epstein-Barr virus, containing the 12 bp palindromic consensus TAGCATATGCTA. The sequence selectivity in the binding of distamycin to DNA was evaluated by footprinting experiments, while the effects of distamycins on DNA-protein interactions was analysed by means of electrophoretic mobility shift assay. The data presented in this paper suggest that distamycin andits analogues differentially inhibit the interaction between DNA-binding proteins and target DNA sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:07:37