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Titolo:
BURN-INDUCED NITRIC-OXIDE RELEASE IN HUMANS
Autore:
GAMELLI RL; GEORGE M; SHARPPUCCI M; DRIES DJ; RADISAVLJEVIC Z;
Indirizzi:
LOYOLA UNIV,MED CTR,INST BURN & SHOCK TRAUMA,2160 S 1ST AVE,BLDG 110-4TH MAYWOOD IL 60153
Titolo Testata:
The journal of trauma, injury, infection, and critical care
fascicolo: 5, volume: 39, anno: 1995,
pagine: 869 - 878
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-ARGININE; RELAXING FACTOR; DEPENDENT MECHANISM; LIPID-PEROXIDATION; MURINE MACROPHAGES; MOUSE MACROPHAGES; HUMAN-NEUTROPHILS; CYTO-TOXICITY; SUPEROXIDE; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Gamelli et al., "BURN-INDUCED NITRIC-OXIDE RELEASE IN HUMANS", The journal of trauma, injury, infection, and critical care, 39(5), 1995, pp. 869-878

Abstract

Nitric oxide (NO) generation in a series of 20 burn patients was studied with a novel anion exchange high-performance liquid chromatographic method for the simultaneous determination of nitrite (NO2-) and nitrate (NO3-), the stable metabolic endproducts of NO. The NO values within our survivor group (n = 17) were significantly altered at days 1, 6, and 12 postburn in contrast to controls (n = 23) (p less than or equal to 0.03). NO2- values were significantly depressed in both plasma and urine, whereas NO,values were significantly elevated in contrast tocontrol values (p less than or equal to 0.03), The ratio of NO2-:NO3-was significantly lower for burn patients versus controls in both plasma and urine (p < 0.01), The NO generation seemed in part to be dependent on the percentage of total body surface area burn, most dramatically elevated in patients with burns of 10 to 40% total body surface area, In subjects who did not survive beyond 36 hours postinjury becauseof irreversible shock (n = 3), the production of NO was significantlydepressed in contrast to survivors and controls (p < 0.0001), However, the NO2-:NO3- ratio (0.001) was relatively unchanged, with reflection of a global depression in NO formation with no change in the individual component release. Burn injury resulted in an increased release/production of NO that in the first postburn week is maximally elevated immediately postinjury, NO release, although decreased at day 6 relative to the day 1 values, remained elevated into the second week postinjury when there was evidence for a further increase in NO production, The enhanced NO3- formation may well result from NO reacting with oxygen-free radicals counteracting superoxide anion-induced destruction of tissue, thereby potentially functioning as a protectant molecule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:48:31