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Titolo:
MOLECULAR CHARACTERIZATION OF A CHROMOSOME-TRANSLOCATION BREAKPOINT T(11-14)(P13-Q11) FROM THE CELL-LINE KOPT-K1
Autore:
DONG WF; XU Y; HU QL; MUNROE D; MINOWADA J; HOUSMAN DE; MINDEN MD;
Indirizzi:
500 SHERBOURNE ST TORONTO ON M4X 1K9 CANADA UNIV TORONTO,PRINCESS MARGARET HOSP,ONTARIO CANC INST,DEPT MED TORONTO ON CANADA UNIV TORONTO,PRINCESS MARGARET HOSP,ONTARIO CANC INST,DEPT MED BIOPHYS TORONTO ON CANADA UNIV TORONTO,PRINCESS MARGARET HOSP,ONTARIO CANC INST,INST MED SCI TORONTO ON CANADA MIT CAMBRIDGE MA 00000 FUJISAKI CELL CTR OKAYAMA JAPAN
Titolo Testata:
Leukemia
fascicolo: 11, volume: 9, anno: 1995,
pagine: 1812 - 1817
SICI:
0887-6924(1995)9:11<1812:MCOACB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIM MOTIF; T-CELLS; LEUKEMIA; DELTA; GENE; PROTEIN; DOMAIN; 11P13; TUMORS; REGION;
Keywords:
ALL; KOPT-K1; CHROMOSOME TRANSLOCATION; RBTN-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W.F. Dong et al., "MOLECULAR CHARACTERIZATION OF A CHROMOSOME-TRANSLOCATION BREAKPOINT T(11-14)(P13-Q11) FROM THE CELL-LINE KOPT-K1", Leukemia, 9(11), 1995, pp. 1812-1817

Abstract

Recurrent chromosome translocations involving 11p13 and 14q11 are found in 5-10% of cases of T-ALL. The gene involved in the translocation on chromosome 14 is the T cell antigen receptor alpha or delta. The putative oncogene on chromosome 11 is rhombotin 2 (RBTN2)/translocated in T cell gene 2 (ttg-2), a member of the LIM family of proteins. In this paper we characterize a cell line KOPT-K1 that has a t(11;14)(p13;q11). The breakpoint on chromosome 11 involves an Alu-rich region with the break occurring between two Alu sequences on chromosome 11. In addition, approximately 70 bases from the break on chromosome 11 is a tetranucleotide repeat. Whether either of these structures played a role in the translocation is not known. No heptamer or nonamer sequences, implicated in other rearrangements were found near the breakpoint. The breakpoint on chromosome 11 maps more centromeric than previous translocations of this region. Despite this the RBTN2 gene is highly expressed in KOPT-K1. This cell line will be useful for investigating the role of RBTN2 in leukemogenesis and the mechanism by which the translocation alters the expression of RBTN2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:13:34