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Titolo:
GAMMOPATHY WITH 2 M-COMPONENTS IN A DOG WITH IGA-TYPE MULTIPLE-MYELOMA
Autore:
KATO H; MOMOI Y; OMORI K; YOUN HY; YAMADA T; GOTO N; ONO K; WATARI T; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU,1-1-1 YAYOI TOKYO 113 JAPAN UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU TOKYO 113 JAPAN UNIV TOKYO,FAC AGR,DEPT VET CLIN PATHOBIOL,BUNKYO KU TOKYO 113 JAPAN AZABU UNIV,SCH VET MED,DEPT VET INTERNAL MED SAGAMIHARA KANAGAWA 229 JAPAN UNIV TOKYO,FAC AGR,DEPT VET PATHOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 1-2, volume: 49, anno: 1995,
pagine: 161 - 168
SICI:
0165-2427(1995)49:1-2<161:GW2MIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
DOG; MULTIPLE MYELOMA; IGA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H. Kato et al., "GAMMOPATHY WITH 2 M-COMPONENTS IN A DOG WITH IGA-TYPE MULTIPLE-MYELOMA", Veterinary immunology and immunopathology, 49(1-2), 1995, pp. 161-168

Abstract

A 12-year-old neutered male mixed-breed dog was referred to hospital for evaluation of chronic diarrhea. Cellulose acetate electrophoresis of its serum revealed two monoclonal peaks in the gamma-globulin fraction. On immunoelectrophoretic analysis, the two monoclonal peaks in the gamma-globulin region were strongly precipitated with anti-dog IgA serum. On sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis, the fractions corresponding to these two peaks were shown to bedimer and trimer or tetramer of immunoglobulin consisting of heavy and light chains. These results indicated that the studied dog had gammopathy with two M-components with dimer and trimer or tetramer of IgA. Accumulations of large amounts of these immunoglobulins with very highmolecular weight in the serum were concluded to induce the hyperviscosity syndrome in this dog in the terminal stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 20:44:39