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Titolo:
HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL SUBFRACTIONS IN OLDER-PEOPLE
Autore:
ETTINGER WH; VERDERY RB; WAHL PW; FRIED LP;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,MED CTR BLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27157 UNIV ARIZONA,ARIZONA CTR AGING TUCSON AZ 00000 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205
Titolo Testata:
Journal of gerontology
fascicolo: 3, volume: 49, anno: 1994,
pagine: 116 - 122
SICI:
0022-1422(1994)49:3<116:HCSIO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; MYOCARDIAL-INFARCTION; PLASMA-LIPIDS; CORONARY ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE; HEART-DISEASE; RISK-FACTORS; A-II; MEN; HDL2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Ettinger et al., "HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL SUBFRACTIONS IN OLDER-PEOPLE", Journal of gerontology, 49(3), 1994, pp. 116-122

Abstract

Background. High density lipoprotein (HDL) may be an important risk factor for cardiovascular disease in older people. HDL is heterogeneouswith several subfractions. This article describes the distribution and correlates of HDL2 cholesterol (C) and HDL3-C in older people. Methods. HDL subfraction cholesterols were measured in 1,127 females and 825 males greater than or equal to 65 years old who participated in the Cardiovascular Health Study. Distributions of HDL subfraction cholesterols and bivariate and multivariate relationships were determined in cross-sectional analyses. Results. Mean (+/- SD) concentrations of HDL subfractions were: HDL3-C (M .98 +/- .25, F 1.2 +/- .29 mmol/l), HDL2-C (M .09 +/- .08, F .13 +/- .09 mmol/l). HDL2-C, but not HDL3-C, was slightly higher with age. Using multivariate analysis, both HDL2-C and HDL3-C (in females) were inversely correlated with triglyceride, body weight, and fasting insulin. HDL3-C was inversely correlated with central fat distribution in women. Both HDL2-C and HDL3-C were lower in participants with prevalent cardiovascular disease. However, only HDL3-Cwas significantly inversely related to carotid stenosis, as measured by ultrasound. Conclusions. The slight increase in HDL-C with age appears to be due to an increase in the HDL2-C subfraction. HDL-C subfractions are independently related to triglyceride levels, body weight, and insulin concentrations in older people, all potentially modifiable risk factors. Both HDL2-C and HDL3-C are lower in older people with prevalent cardiovascular disease, although only HDL3-C was correlated with carotid atherosclerosis. These findings are consistent with the hypothesis that HDL subfractions are important risk factors for atherosclerotic cardiovascular disease in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:46:14