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Titolo:
RU-24969-INDUCED LOCOMOTION IN RATS IS MEDIATED BY 5HT(1A) RECEPTORS
Autore:
KALKMAN HO;
Indirizzi:
SANDOZ PHARMA LTD,PRECLIN RES,BLDG 360-405 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 5, volume: 352, anno: 1995,
pagine: 583 - 584
SICI:
0028-1298(1995)352:5<583:RLIRIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RU-24969;
Keywords:
WAY-100635; GR 127935; SDZ; 216-525; RU 24969; LOCOMOTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
H.O. Kalkman, "RU-24969-INDUCED LOCOMOTION IN RATS IS MEDIATED BY 5HT(1A) RECEPTORS", Naunyn-Schmiedeberg's archives of pharmacology, 352(5), 1995, pp. 583-584

Abstract

The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT1B receptoragonist, was investigated in the rat, using two novel 5-HT1A receptorantagonists, WAY-100635 (0.3 mg/kg and 1 mg/kg, s.c.) and SDZ 216-525(0.3 mg/kg, s.c.), and the novel 5-HT1B/5-HT1D receptor antagonist, GR 127935 (1 mg/kg, s.c.). The antagonists per se did not alter spontaneous locomotion. Both selective 5-HT1A receptor antagonists blocked RU24969-induced hyperlocomotion, whilst the 5-HT1B receptor antagonist was without effect. These results suggest that RU 24969-induced hyperlocomotion in the rat is mediated by 5-HT1A receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:16:20