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Titolo:
INTRAVESICAL APPLICATION OF OXYBUTYNINE - MODE OF ACTION IN CONTROLLING DETRUSOR HYPERREFLEXIA - PRELIMINARY-RESULTS
Autore:
MADERSBACHER H; KNOLL M;
Indirizzi:
UNIV INNSBRUCK HOSP,NEUROUROL UNIT,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA KRANKENHAUS STADT WIEN LAINZ,DEPT UROL VIENNA AUSTRIA
Titolo Testata:
European urology
fascicolo: 4, volume: 28, anno: 1995,
pagine: 340 - 344
SICI:
0302-2838(1995)28:4<340:IAOO-M>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORIDE; INSTILLATION; PHARMACOKINETICS; HYDROCHLORIDE; RELAXATION; BLADDERS;
Keywords:
OXYBUTYNINE; INTRAVESICAL; PHARMACOKINETICS OF OXYBUTYNINE; DETRUSOR HYPERREFLEXIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
H. Madersbacher e M. Knoll, "INTRAVESICAL APPLICATION OF OXYBUTYNINE - MODE OF ACTION IN CONTROLLING DETRUSOR HYPERREFLEXIA - PRELIMINARY-RESULTS", European urology, 28(4), 1995, pp. 340-344

Abstract

Topical oxybutynine (Oxy) has been used successfully in neurogenic bladder patients who remained wet on oral anticholinergics or could not tolerate oral medication. However, little is known about the pharmacokinetics of intravesical Oxy. The aim of this study was to evaluate theresorption rate of intravesically given Oxy in the bladder in comparison with oral intake, and to find out which pharmacological propertiesof the drug are responsible for its effect when given intravesically. Our results indicate that peak plasma levels of intravesical Oxy appear later, are lower and stay longer compared to oral intake. Cystometries before, 20 min and 2 h after intravesical application of Oxy indicate that the main effect of intravesical Oxy on the detrusor is systemic due to its resorption. Our findings confirm the clinical experiencethat intravesical Oxy is well tolerated, very efficacious and better than oral medication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:35:12