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Titolo:
INHIBITION OF 1,2-DIMETHYLHYDRAZINE-INDUCED OXIDATIVE DNA-DAMAGE BY GREEN TEA EXTRACT IN RAT
Autore:
INAGAKE M; YAMANE T; KITAO Y; OYA K; MATSUMOTO H; KIKUOKA N; NAKATANI H; TAKAHASHI T; NISHIMURA H; IWASHIMA A;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT SURG 1,KAMIKYO KU KYOTO 602 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU KYOTO 602 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 11, volume: 86, anno: 1995,
pagine: 1106 - 1111
SICI:
0910-5050(1995)86:11<1106:IO1ODB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED COLON CARCINOGENESIS; (-)-EPIGALLOCATECHIN GALLATE; OXYGEN RADICALS; DRINKING-WATER; DIMETHYLHYDRAZINE; O6-METHYLGUANINE; POLYPHENOLS; SKIN; MICE; 8-HYDROXYDEOXYGUANOSINE;
Keywords:
8-HYDROXYDEOXYGUANOSINE; GREEN TEA; 1,2-DIMETHYLHYDRAZINE; COLON CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Inagake et al., "INHIBITION OF 1,2-DIMETHYLHYDRAZINE-INDUCED OXIDATIVE DNA-DAMAGE BY GREEN TEA EXTRACT IN RAT", Japanese journal of cancer research, 86(11), 1995, pp. 1106-1111

Abstract

Following subcutaneous injection of 1,2-dimethylhydrazine (DMH), which is carcinogenic to rat colon and liver, to Sprague-Dawley rats, a significant increase of 8-hydroxydeoxyguanosine (8-OHdG) was observed inthe DNA of colonic mucosa and liver. The 8-OHdG formation reached themaximal level at about 24 h after the DMH injection. On the other hand, no increase of 8-OHdG was observed in the DNA of the kidney. Drinking green tea extract (GTE) for ten days prior to the DMH injection significantly inhibited the formation of 8-OHdG in the colon. These findings demonstrate that DMH causes oxidative damage to the DNA of its target organ, and that GTE protects colonic mucosa from this oxidative damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:25:22