Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AEROSOL DERIVED AIRWAY MORPHOMETRY IN HEALTHY-SUBJECTS
Autore:
BRAND P; RIEGER C; BEINERT T; HEYDER J;
Indirizzi:
GSF,FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL,ROBERT KOCH ALLEE 6 D-82131 GAUTING GERMANY GSF,FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL D-82131 OBERSCHLEISSHEIM GERMANY
Titolo Testata:
The European respiratory journal
fascicolo: 10, volume: 8, anno: 1995,
pagine: 1639 - 1646
SICI:
0903-1936(1995)8:10<1639:ADAMIH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-INFLATION; DEPOSITION;
Keywords:
AEROSOL-DERIVED AIRWAY MORPHOMETRY; AGING LUNG; HEALTHY SUBJECTS; INTERSUBJECT VARIABILITY; LUNG INFLATION; LUNG MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P. Brand et al., "AEROSOL DERIVED AIRWAY MORPHOMETRY IN HEALTHY-SUBJECTS", The European respiratory journal, 8(10), 1995, pp. 1639-1646

Abstract

Monodisperse aerosol particles can be used to non-invasively probe intrapulmonary airspace dimensions, In this study, the aerosol-derived airway morphometry technique was used to study airspace dimensions in 79 healthy subjects, in order to assess reference data for the future clinical application of aerosol-derived airway morphometry, and to investigate the effect of lung inflation, anthropometric, and lung function parameters on aerosol-derived airway morphometry, Intrapulmonary airspace dimensions were assessed by measuring the deposition of monodisperse, hydrophobic submicron aerosol particles during breathholding. Additionally, measurements of spirometric and body plethysmographic lungfunction were performed, Airspace dimensions were in good agreement with morphometric lung data, Airspace dimensions increased with increasing lung inflation. Interindividual variation of airspace dimensions was lowest in the lung periphery, at high levels of lung inflation, andwhen the volumetric lung depth was normalized to the end-inspiratory lung volume, Analysis of variance showed an increase of airspace dimensions with age, The results of this study indicate that aerosol-derived airway morphometry is dependent on the level of lung inflation and the age of the subject, These results suggest that in contrast to conventional lung function techniques, aerosol-derived airway morphometry might be a powerful tool for the detection of small changes in peripheral airway geometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:17:32