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Titolo:
EFFECTS OF LYMPHOCYTE SUBPOPULATIONS ON THE CLONAL ASSAY OF HPRT MUTANTS - OCCUPATIONAL EXPOSURE TO CYTOSTATIC DRUGS
Autore:
DUBEAU H; ZAZI W; BARON C; MESSING K;
Indirizzi:
UNIV QUEBEC,DEPT SCI BIOL,CINBIOSE,CP 8888,SUCCURSALE A MONTREAL H3C 3P8 PQ CANADA
Titolo Testata:
MUTATION RESEARCH
fascicolo: 3, volume: 321, anno: 1994,
pagine: 147 - 157
SICI:
0027-5107(1994)321:3<147:EOLSOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PERIPHERAL-BLOOD; 6-THIOGUANINE-RESISTANT LYMPHOCYTES; MONOCLONAL-ANTIBODIES; MUTATION FREQUENCY; BREAST-CANCER; IONIZING-RADIATION; T SUBPOPULATIONS; HUMAN-POPULATION; CLONING ASSAY; CELL CLONING;
Keywords:
CHEMOTHERAPY; HPRT(-) MUTANT FREQUENCY; CLONING EFFICIENCY; HPRT(-) MUTANTS; T-LYMPHOCYTES SUBSETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
H. Dubeau et al., "EFFECTS OF LYMPHOCYTE SUBPOPULATIONS ON THE CLONAL ASSAY OF HPRT MUTANTS - OCCUPATIONAL EXPOSURE TO CYTOSTATIC DRUGS", MUTATION RESEARCH, 321(3), 1994, pp. 147-157

Abstract

The mutagenic effect of occupational exposure to antineoplastic agents was studied in chemotherapy nurses and pharmacists using the T-lymphocyte clonal assay. A significant increase in mutant frequency was observed compared to controls. However, in the present study, cloning efficiency without selection (CE(U)) was significantly reduced in exposedpersonnel raising the possibility of an overestimation of the calculated MF. Changes in lymphocyte populations and clonal potential of T-cells were also observed following exposure. CE(U) was related to % CD4 cells but CE with selection (CE(TG)) was not. Differences in clonal ability of T-cells under selective and unselective conditions coupled with differential lethal effect of antineoplastic agents on lymphocyte subsets may result in inaccurate estimation of MF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:09:03