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Titolo:
STUDIES ON THE METABOLISM OF [1-C-14]5.8.11-EICOSATRIENOIC (MEAD) ACID IN RAT HEPATOCYTES
Autore:
RETTERSTOL K; WOLDSETH B; CHRISTOPHERSEN BO;
Indirizzi:
UNIV OSLO,RIKSHOSP,INST CLIN BIOCHEM N-0027 OSLO NORWAY
Titolo Testata:
Biochimica et biophysica acta, L. Lipids and lipid metabolism
fascicolo: 1, volume: 1259, anno: 1995,
pagine: 82 - 88
SICI:
0005-2760(1995)1259:1<82:SOTMO[>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; LIVER-CELLS; 5,8,11-EICOSATRIENOIC ACID; CHAIN ELONGATION; ARACHIDONIC-ACID; FATTY-ACIDS; RETROCONVERSION; PHOSPHOLIPIDS; DESATURATION; SEPARATION;
Keywords:
MEAD ACID; ARACHIDONIC ACID; ICOSAPENTAENOIC ACID; PHOSPHOLIPID; ESSENTIAL FATTY ACID; (RAT HEPATOCYTE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Retterstol et al., "STUDIES ON THE METABOLISM OF [1-C-14]5.8.11-EICOSATRIENOIC (MEAD) ACID IN RAT HEPATOCYTES", Biochimica et biophysica acta, L. Lipids and lipid metabolism, 1259(1), 1995, pp. 82-88

Abstract

The oxidation, esterification and formation of chain elongated and desaturated products of [1-C-14]5,8,11-eicosatrienoic (Mead) acid was studied. Liver cells from essentially fatty acid deficient (EFAD) and control rats were used. The metabolism of [1-C-14]20:4,n-6 and [1-C-14]20:5,n-3 were studied under the same experimental conditions. More 20:3,n-9 than 20:4,n-6 and 20:5,n-3 was oxidised both in EFAD and control cells. 20:3,n-9 was elongated to [C-14]22:3,n-9 in both cell types andsignificant amounts of [C-14]22:4,n-9 were formed in EFAD cells. Less20:3,n-9 was esterified in phospholipids and more in triacylglycerol than observed with 20:4,n-6 and 20:5,n-3 in both cell types, 20:3,n-9 was mainly esterified in phosphatidylcholine and little was esterifiedin phosphatidylethanolamine compared to 20:4,n-6 and 20:5,n-3. In comparison, 20:3,n-9 was rather efficiently esterified in phosphatidylinositol as 18:0-20:3. [C-14]22:4,n-9 formed from 20:3,n-9 in EFAD hepatocytes was esterified in triacylglycerol, not in phospholipids, unlike [C-14]22:5,n-6 and [C-14]22:6,n-3 which were mainly esterified in phospholipids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:29:44