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Titolo:
PHASE-I TRIAL OF DIAZIQUONE (AZQ) PLUS GM-CSF
Autore:
HARTMANN LC; AMES MM; REID JM; RICHARDSON RL;
Indirizzi:
MAYO CLIN,DIV MED ONCOL,200 SW 1ST ST ROCHESTER MN 55905
Titolo Testata:
Investigational new drugs
fascicolo: 2, volume: 13, anno: 1995,
pagine: 175 - 176
SICI:
0167-6997(1995)13:2<175:PTOD(P>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Keywords:
DIAZIQUONE; AZQ; GM-CSF;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
L.C. Hartmann et al., "PHASE-I TRIAL OF DIAZIQUONE (AZQ) PLUS GM-CSF", Investigational new drugs, 13(2), 1995, pp. 175-176

Abstract

Diaziquone (AZQ) is a lipid soluble alkylating agent which was designed for increased CNS penetration. Its principle toxicity is myelosuppression. We conducted a phase I trial using AZQ in combination with GM-CSF to determine if the maximal tolerated dose (MTD) of AZQ could be escalated. Using GM-CSF on a standard schedule, we were unable to escalate the previously determined MTD of diaziquone with the use of this colony stimulating factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:44:45