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Titolo:
UTILITY OF FOLLOW-UP TESTS FOR DETECTING RECURRENT DISEASE IN PATIENTS WITH MALIGNANT MELANOMAS
Autore:
WEISS M; LOPRINZI CL; CREAGAN ET; DALTON RJ; NOVOTNY P; OFALLON JR;
Indirizzi:
MAYO CLIN & MAYO FDN,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN ROCHESTER MN 55905 DULUTH COMMUNITY CLIN ONCOL PROGRAM DULUTH MN 00000
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 21, volume: 274, anno: 1995,
pagine: 1703 - 1705
SICI:
0098-7484(1995)274:21<1703:UOFTFD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; GUIDELINES; POLICY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Weiss et al., "UTILITY OF FOLLOW-UP TESTS FOR DETECTING RECURRENT DISEASE IN PATIENTS WITH MALIGNANT MELANOMAS", JAMA, the journal of the American Medical Association, 274(21), 1995, pp. 1703-1705

Abstract

Objective.-To determine the effectiveness of follow-up tests for signaling recurrences in patients with intermediate- and high-risk malignant melanomas treated with curative intention. Design.-Retrospective analysis of prospectively collected data. Setting.-North Central Cancer Treatment Group. Patients.-A total of 261 patients with resected local(greater than or equal to 1.69 mm) and regional nodal malignant melanomas who were enrolled in a single prospective adjuvant trial were studied. All patients were scheduled to be followed up monthly for 2 months, then every 2 months for the first year, every 4 months the second year, every 6 months the next 3 years, and annually thereafter, with each visit consisting of a history, physical examination, complete blood cell count, blood chemistry panel, and a chest x-ray. Results.-Of the 145 evaluable patients who developed recurrent melanomas, 99 patients (68%) developed symptoms that signaled the diagnosis of recurrent disease. Physical examination of asymptomatic patients led to the diagnosis of recurrent disease in 37 patients (26%). The other nine patients(6%) with recurrent disease had abnormal chest x-rays. Laboratory results were never a sole indicator of recurrent disease. Conclusion.-Themajority of recurrences following resection of primary melanomas are discovered by history and/or physical examination despite the frequentuse of other follow-up tests. The present data indicate that routine blood analyses and chest x-rays have limited value in the postoperative follow-up of patients with resected intermediate- and high-risk melanomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:01:06