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Titolo:
CYTOREDUCTION AND SEQUENTIAL RESECTION FOR SURGICALLY VERIFIED UNRESECTABLE HEPATOCELLULAR-CARCINOMA - EVALUATION WITH ANALYSIS OF 72 PATIENTS
Autore:
TANG ZY; YU YQ; ZHOU XD; MA ZC; LU JZ; LIN ZY; LIU KD; YE SL; YANG BH; WANG HW; SUN HC;
Indirizzi:
SHANGHAI MED UNIV,INST LIVER CANC,399 LING LING RD SHANGHAI 200032 PEOPLES R CHINA
Titolo Testata:
World journal of surgery
fascicolo: 6, volume: 19, anno: 1995,
pagine: 784 - 789
SICI:
0364-2313(1995)19:6<784:CASRFS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY LIVER-CANCER; HEPATIC-ARTERY LIGATION; MULTIMODALITY TREATMENT; TARGETING THERAPY; CHEMOTHERAPY; RADIOIMMUNOTHERAPY; HEPATOBLASTOMA; INFUSION; SURGERY; HCC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Z.Y. Tang et al., "CYTOREDUCTION AND SEQUENTIAL RESECTION FOR SURGICALLY VERIFIED UNRESECTABLE HEPATOCELLULAR-CARCINOMA - EVALUATION WITH ANALYSIS OF 72 PATIENTS", World journal of surgery, 19(6), 1995, pp. 784-789

Abstract

The poor prognosis of hepatocellular carcinoma (HCC) was partly a result of the majority of unresectable HCCs in clinical patients. Fortunately, with the progress of regional cancer therapies and multimodalitytreatment, some of the localized unresectable HCCs were converted to resectable ones. During the period 1960-1994, 72 of the 663 patients with surgically verified unresectable HCCs have been converted to resectable. Successful cytoreduction with median diameter reduced from 10 cm to 5 cm was mainly a result of the triple or double combination treatment with hepatic artery ligation, hepatic artery cannulation with infusion, radioimmunotherapy, and fractionated regional radiotherapy. The interval between the first operation and the sequential resection was 5 months. The operative mortality was 1.4%, for sequential resection, and the 5-year survival was 62.1%. Analysis of factors influencing sequential resection rate revealed HCCs that were single nodule, well encapsulated, situated at right Lobe or hepatic hilum, associated with micronodular cirrhosis, and treated with triple or double combination modalities had higher sequential resection rate as compared to their counterparts. Analysis of factors influencing survival after sequentialresection revealed that HCCs with a solitary tumor confined in one lobe, without tumor embolus, and without residual cancer in specimen of sequential resection, had longer survival. It is suggested that localized unresectable, solitary, well encapsulated, right lobe or hilar HCC, associated with micronodular cirrhosis, will be good candidates for cytoreduction and sequential resection; and HCCs with unilateral involvement, without tumor embolus, and with complete necrosis of tumor after multimodality treatment favored better prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:59:52