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Titolo:
THE CONTRASTING INFLUENCE OF CHRONIC NICOTINE INTAKE ON GASTRIN AND GASTRIC-ACID SECRETION
Autore:
WONG D; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,SCH POSTGRAD MED EDUC & TRAINING,1-F PATRICK MANSION BLDG S WING HONG KONG HONG KONG UNIV HONG KONG,FAC MED,SCH POSTGRAD MED EDUC & TRAINING HONG KONG HONG KONG UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG
Titolo Testata:
Journal of gastroenterology and hepatology
fascicolo: 5, volume: 10, anno: 1995,
pagine: 577 - 584
SICI:
0815-9319(1995)10:5<577:TCIOCN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT STOMACH; SOMATOSTATIN SECRETION; RECEPTOR STIMULATION; PARIETAL-CELLS; ANTRAL MUCOSA; HISTAMINE; ULCERATION; NEURONS; MECHANISMS; INHIBITION;
Keywords:
GASTRIN; MUCOSAL THICKNESS; NICOTINE; PARIETAL CELLS; PENTAGASTRIN; RATS; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D. Wong e C.W. Ogle, "THE CONTRASTING INFLUENCE OF CHRONIC NICOTINE INTAKE ON GASTRIN AND GASTRIC-ACID SECRETION", Journal of gastroenterology and hepatology, 10(5), 1995, pp. 577-584

Abstract

The effects of chronic nicotine treatment on gastric acid secretion stimulated by subcutaneous injection of pentagastrin, as well as on serum gastrin levels and the stomach parietal cell population, were examined. Rats drank a solution of nicotine 25 mu g/mL tap water for periods of 10, 30 or 45 days. Pentagastrin increased the gastric secretory volume and acid output in pylorus-ligated control animals that drank tap water. Animals given nicotine in their drinking water for 10, 30 or 45 days showed increased basal gastric secretion and acid output. Pentagastrin produced maximum stimulatory effects at lower dose levels of 50 mu g/kg in the 10-day treatment group and 25 mu g/kg in the 30- or 45-day treatment groups; however, the maximum responses to pentagastrin in all nicotine-treated batches were comparable to those of their corresponding controls. Serum gastrin levels remained unchanged from the10th day of nicotine treatment, whereas the levels in the control animals continued to rise with age. Nicotine 25 mu g/mL drinking water given for 10, 30 or 45 days caused no significant changes in the parietal cell population, mucosal surface area or mucosal thickness. These findings are consistent with the idea that chronic nicotine administration, for at least 10 days, will lead to increased muscarinic receptor sensitivity; basal acid secretion is consequently elevated, and this inturn may depress gastrin secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:43:14