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Titolo:
NEW APPROACHES TO THE TREATMENT OF PATIENTS WITH ACUTE, NONSPECIFIC DIARRHEA - A COMPARISON OF THE EFFECTS OF LOPERAMIDE AND LOPERAMIDE OXIDE
Autore:
VANDENEYNDEN B; SPAEPEN W;
Indirizzi:
MECHELSESTEENWEG 9 B-2640 MORSTEL BELGIUM
Titolo Testata:
Current therapeutic research
fascicolo: 11, volume: 56, anno: 1995,
pagine: 1132 - 1141
SICI:
0011-393X(1995)56:11<1132:NATTTO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ELECTROLYTE TRANSPORT; PROSPECTS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
B. Vandeneynden e W. Spaepen, "NEW APPROACHES TO THE TREATMENT OF PATIENTS WITH ACUTE, NONSPECIFIC DIARRHEA - A COMPARISON OF THE EFFECTS OF LOPERAMIDE AND LOPERAMIDE OXIDE", Current therapeutic research, 56(11), 1995, pp. 1132-1141

Abstract

The effects of loperamide oxide 1 mg and 2 mg were compared with placebo and with loperamide 2 mg in 261 patients with acute, nonspecific diarrhea, Time to first relief and time to complete relief of diarrhea were statistically significantly shorter in the three active drug groups than in the placebo group, Compared with placebo, neither dosage ofloperamide oxide produced a period of posttreatment constipation, Adverse experiences were (nonsignificantly) less frequent for loperamide oxide 1 mg and 2 mg than for either placebo or loperamide 2 mg, These results suggest that loperamide oxide 1 mg is as efficacious as loperamide 2 mg for the treatment of patients with acute, nonspecific diarrhea, Because of its low potential for causing constipating effects and adverse experiences, loperamide oxide 1 mg may be preferred over either loperamide oxide 2 mg or loperamide 2 mg.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:36:47