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Titolo:
THE LITHIUM TEST DOSE PREDICTION METHOD IN AGGRESSIVE-CHILDREN
Autore:
MALONE RP; DELANEY MA; LUEBBERT JF; WHITE MA; BIESECKER KA; COOPER TB;
Indirizzi:
HAHNEMANN UNIV,DEPT PSYCHIAT,MAIL STOP 403,BROAD & VINE ST PHILADELPHIA PA 19102 NATHAN S KLINE INST PSYCHIAT RES,ANALYT PSYCHOPHARMACOL LAB ORANGEBURG NY 10962
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 2, volume: 31, anno: 1995,
pagine: 379 - 381
SICI:
0048-5764(1995)31:2<379:TLTDPM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPUBERTAL CHILDREN; DOSAGE REQUIREMENTS; LEVEL; PROGNOSTICATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Malone et al., "THE LITHIUM TEST DOSE PREDICTION METHOD IN AGGRESSIVE-CHILDREN", Psychopharmacology bulletin, 31(2), 1995, pp. 379-381

Abstract

Cooper and associates (1973) developed a method of ascertaining the lithium dosage required to attain a therapeutic serum level of 0.6 to 1.2 mEq/L. However, reports about the safety and accuracy of their method in children are limited (Geller & Fetner 1989). This study relates our experience with using this method in children. Subjects were 16 conduct-disordered children (13 males, 3 females), ages 8.97 to 17.14 years (mean, 12.73+/-2.12), who were treated with lithium to decrease aggressive behavior. Following a lithium 600-mg loading dose, a 24-hour serum lithium level was drawn from which a ''predicted'' lithium dosage was established. These dosages ranged from 600 to 1,800 mg/day (mean, 1,312.5+/-450) and the corresponding serum lithium levels at steady-state ranged from 0.58 to 1.13 mEq/L (mean, 0.87+/-0.15). No severe side effects were encountered. This suggests that the method is safe anduseful for predicting lithium dosages in children.

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Documento generato il 07/07/20 alle ore 14:49:41