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Titolo:
A COMPARISON OF EUROPEAN AND AMERICAN DOSING REGIMENS OF SCHIZOPHRENIC-PATIENTS ON CLOZAPINE - EFFICACY AND SIDE-EFFECTS
Autore:
POLLACK S; LIEBERMAN JA; FLEISCHHACKER WW; BORENSTEIN M; SAFFERMAN AZ; HUMMER M; KURZ M;
Indirizzi:
LONG ISL JEWISH MED CTR,HILLSIDE HOSP,RES DEPT,76TH AVE & 266TH ST GLEN OAKS NY 11004 ST JOHNS UNIV,DEPT QUANTITAT ANAL JAMAICA NY 11439 ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT BRONX NY 10467 INNSBRUCK UNIV CLIN,DEPT BIOL PSYCHIAT INNSBRUCK AUSTRIA PFIZER INC NEW YORK NY 00000
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 2, volume: 31, anno: 1995,
pagine: 315 - 320
SICI:
0048-5764(1995)31:2<315:ACOEAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARDIVE-DYSKINESIA; PLASMA-LEVELS;
Keywords:
SCHIZOPHRENIA; OPTIMAL DOSE; CLOZAPINE; SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Pollack et al., "A COMPARISON OF EUROPEAN AND AMERICAN DOSING REGIMENS OF SCHIZOPHRENIC-PATIENTS ON CLOZAPINE - EFFICACY AND SIDE-EFFECTS", Psychopharmacology bulletin, 31(2), 1995, pp. 315-320

Abstract

We present a comparison of the results from two studies of patients on clozapine. The American study (n=84; Hillside Hospital, Glen Oaks, NY) and the European study (n=63; Innsbruck University Clinics, Innsbruck, Austria) both examine efficacy and side effects in schizophrenic patients on this atypical neuroleptic. There is a very substantial difference in the dosing regimen used on both continents and this is reflected in the studies reported. A question with major clinical implications is whether the higher doses commonly used in the United States lead to a better outcome or a different profile of side effects. Outcome as a function of serum concentration will be examined. Results confirma lower dose, lower clozapine blood level, and a lesser degree of side effects in the Austrian cohort when compared to the American sample. Surprisingly, the clinical efficacy of the lower dosing regimen was superior to the higher dose. Reasons for this anomaly are explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:09:31