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Titolo:
KINETICS OF CD2-INJECTION OF CD-METALLOTHIONEIN-II( IN PLASMA, LIVER AND KIDNEYS AFTER SINGLE INTRAVENOUS)
Autore:
SUDO J; HAYASHI T; TERUI J; SOYAMA M; FUKATA M; KAKUNO K;
Indirizzi:
HIGASHI NIPPON GAKUEN UNIV,FAC PHARMACEUT SCI,DEPT CLIN PHARMACOL & TOXICOL ISHIKARI HOKKAIDO 06102 JAPAN
Titolo Testata:
European journal of pharmacology. Environmental toxicology and pharmacology section
fascicolo: 2-3, volume: 270, anno: 1994,
pagine: 229 - 235
SICI:
0926-6917(1994)270:2-3<229:KOCOCI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADMIUM-METALLOTHIONEIN; INDUCED NEPHROPATHY; RENAL TOXICITY; RATS; INJURY; LIGHT; NEPHROTOXICITY; BINDING;
Keywords:
CD2+; METALLOTHIONEIN; NEPHROTOXICITY; HEPATOTOXICITY; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J. Sudo et al., "KINETICS OF CD2-INJECTION OF CD-METALLOTHIONEIN-II( IN PLASMA, LIVER AND KIDNEYS AFTER SINGLE INTRAVENOUS)", European journal of pharmacology. Environmental toxicology and pharmacology section, 270(2-3), 1994, pp. 229-235

Abstract

To explore the kinetics of Cd2+ in the body, rats received a single intravenous injection of CdCl2 or Cd-saturated metallothionein-II at 0.3 mg Cd/kg body weight. Cd2+ in the two agents was biexponentially eliminated from plasma: rapidly in the first 5 min, and gradually later. Compared with CdCl2, Cd-saturated metallothionein-II showed lower Cd2concentrations in plasma during the first 30 min; larger values for parameters concerning distribution of Cd2+, its total body clearance and half-life time in the P phase. Cd2+ uptake in the liver was higher with CdCl2, and, conversely, in the kidneys it was higher with Cd-saturated metallothionein-II. In Cd-saturated metallothionein-II, the renalcontent of Cd2+ reached a maximum (8 mu g Cd2+/g tissue) on day 1, gradually decreasing thereafter; there was a higher area under the Cd2+ content-time curve, and a lower mean residence time of Cd2+; th, kidneys showed severe necrosis and defluxion of proximal tubular cells at days 1 and 5, although there were regenerative and reversion signs on day 5. These findings suggested that, in the case of Cd-saturated metallothionein-II, Cd2+ being taken into the cells of proximal tubules wasexcluded predominantly due to cellular death and the resultant defluxion.

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Documento generato il 02/12/20 alle ore 15:22:49