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Titolo:
EXCLUSION FROM PROXIMAL 11Q OF A COMMON GENE WITH MEGAPHENIC EFFECT ON ATOPY
Autore:
WATSON M; LAWRENCE S; COLLINS A; BEASLEY R; DOULL I; BEGISHVILI B; LAMPE F; HOLGATE ST; MORTON NE;
Indirizzi:
UNIV SOUTHAMPTON,GEN HOSP SOUTHAMPTON SO9 4XY HANTS ENGLAND UNIV SOUTHAMPTON,PRINCESS ANNE HOSP,CTR HUMAN GENET SOUTHAMPTON SO16 5YA HANTS ENGLAND WELLINGTON SCH MED,DEPT MED WELLINGTON NEW ZEALAND
Titolo Testata:
Annals of Human Genetics
, volume: 59, anno: 1995,
parte:, 4
pagine: 403 - 411
SICI:
0003-4800(1995)59:<403:EFP1OA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DINUCLEOTIDE REPEAT POLYMORPHISM; IMMUNOGLOBULIN-E; LINKAGE; CHROMOSOME-11Q; LOCUS; ASTHMA; RESPONSES; MAPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Watson et al., "EXCLUSION FROM PROXIMAL 11Q OF A COMMON GENE WITH MEGAPHENIC EFFECT ON ATOPY", Annals of Human Genetics, 59, 1995, pp. 403-411

Abstract

We have typed three markers on proximal 11q in 131 random families with thr ee or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2-locus disease model, rye performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers wecannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.

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Documento generato il 22/10/20 alle ore 06:43:48