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Titolo:
SYNTHESES OF [6,7-N-15]-ADENOSINE, [6,7-N-15]-2'-DEOXYADENOSINE, AND [7-N-15]-HYPOXANTHINE
Autore:
PAGANO AR; LAJEWSKI WM; JONES RA;
Indirizzi:
RUTGERS STATE UNIV,DEPT CHEM & BIOCHEM ENGN PISCATAWAY NJ 08855 RUTGERS STATE UNIV,DEPT CHEM & BIOCHEM ENGN PISCATAWAY NJ 08855
Titolo Testata:
Journal of the American Chemical Society
fascicolo: 47, volume: 117, anno: 1995,
pagine: 11669 - 11672
SICI:
0002-7863(1995)117:47<11669:SO[[A[>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROGEN-15-LABELED OLIGODEOXYNUCLEOTIDES; N-15 NMR; ENZYMATIC-SYNTHESIS; ADENINE N1; BASE-PAIR; DEOXYNUCLEOSIDES; DEOXYADENOSINE; OLIGONUCLEOTIDES; NUCLEOSIDES; CONVERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Pagano et al., "SYNTHESES OF [6,7-N-15]-ADENOSINE, [6,7-N-15]-2'-DEOXYADENOSINE, AND [7-N-15]-HYPOXANTHINE", Journal of the American Chemical Society, 117(47), 1995, pp. 11669-11672

Abstract

We have developed a high-yield route for the synthesis of [7-N-15]-hypoxanthine in four steps in an overall yield of 81%. This procedure uses [N-15]-sodium nitrite as the N-15 source and an inexpensive pyrimidine to provide an economical route to this useful N-15-labeled intermediate. Conversion to [7-N-15]-6-chloropurine followed by enzymatic transglycosylation gives the corresponding ribo- and 2'-deoxyribonucleosides. Ammonolysis of the 6-chloro moiety to give the [6,7-N-15]-labelednucleosides is effected simply and in high yield using 2 equiv of [N-15]-ammonium chloride and 3 equiv of potassium bicarbonate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 14:54:45