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Titolo:
REPRODUCTIVE RISK-FACTORS FOR COLORECTAL ADENOMATOUS POLYPS (NEW-YORK-CITY, NY, UNITED-STATES)
Autore:
JACOBSON JS; NEUGUT AI; GARBOWSKI GC; AHSAN H; WAYE JD; TREAT MR; FORDE KA;
Indirizzi:
COLUMBIA PRESBYTERIAN MED CTR,DIV ONCOL,630 W 168TH ST NEW YORK NY 10032 MT SINAI SCH MED NEW YORK NY 00000 COLUMBIA UNIV COLL PHYS & SURG NEW YORK NY 10032
Titolo Testata:
CCC. Cancer causes & control
fascicolo: 6, volume: 6, anno: 1995,
pagine: 513 - 518
SICI:
0957-5243(1995)6:6<513:RRFCAP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE BOWEL-CANCER; EXOGENOUS FEMALE HORMONES; BREAST-CANCER; 1ST PREGNANCY; WOMEN; PARITY; EPIDEMIOLOGY; NEOPLASIA; AGE;
Keywords:
ADENOMA; COLORECTAL CANCER; FEMALES; HORMONES; POLYP; REPRODUCTIVE FACTORS; UNITED STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Jacobson et al., "REPRODUCTIVE RISK-FACTORS FOR COLORECTAL ADENOMATOUS POLYPS (NEW-YORK-CITY, NY, UNITED-STATES)", CCC. Cancer causes & control, 6(6), 1995, pp. 513-518

Abstract

Events of reproductive life, such as parity and age at menarche, havebeen found in some but not all studies to be associated with risk forcolorectal cancer in females. Because adenomatous polyps (adenomas) are precursors of colorectal cancer, we investigated whether reproductive variables were associated with colorectal adenomas. We conducted a case-control study among patients examined in three colonoscopy practices in New York City (NY, United States) from 1986 to 1988. Adenoma cases (n = 128) were defined as women who had an adenoma detected at theindex colonoscopy with no history of inflammatory bowel disease, adenomas, or cancer. Controls (n = 283) were women with a normal index colonoscopy and no history of inflammatory bowel disease, adenomas, or cancer. The adjusted odds ratio (OR) for the association of early menarche (age less than 13 years) with adenomas was 0.6 (95 percent confidence interval = 0.4-0.9). Parity, history of spontaneous or induced abortion, infertility, type of menopause, age at menopause, use of oral contraceptives, and use of menopausal hormone replacement therapy were not associated statistically significantly with adenoma risk, although some possible trends were observed Our findings do not implicate reproductive events, nulliparity, or overexposure to estrogens or to menstrual cycles as mechanisms of increased risk for colorectal neoplasia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:54:28