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Titolo:
CEREBRAL BLOOD-FLOW RESERVE ASSESSMENT IN SYMPTOMATIC VERSUS ASYMPTOMATIC HIGH-GRADE INTERNAL CAROTID-ARTERY STENOSIS
Autore:
NIGHOGHOSSIAN N; TROUILLAS P; PHILIPPON B; ITTI R; ADELEINE P;
Indirizzi:
HOP NEUROL,NEUROL SERV,59 BD PINEL F-69003 LYON FRANCE NEUROL HOSP,DEPT NEUROL CEREBROVASC DIS LYON FRANCE NEUROL HOSP,ATAXIA RES CTR LYON FRANCE NEUROL HOSP,DEPT NUCL MED LYON FRANCE UFR ALEXIS CARREL,INFORMAT MED LAB LYON FRANCE
Titolo Testata:
Stroke
fascicolo: 5, volume: 25, anno: 1994,
pagine: 1010 - 1013
SICI:
0039-2499(1994)25:5<1010:CBRAIS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETAZOLAMIDE; OCCLUSION; ENDARTERECTOMY; HEMODYNAMICS; CAMERA; RCBF;
Keywords:
ACETAZOLAMIDE; CAROTID ARTERY DISEASES; CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
N. Nighoghossian et al., "CEREBRAL BLOOD-FLOW RESERVE ASSESSMENT IN SYMPTOMATIC VERSUS ASYMPTOMATIC HIGH-GRADE INTERNAL CAROTID-ARTERY STENOSIS", Stroke, 25(5), 1994, pp. 1010-1013

Abstract

Background and Purpose Thromboembolic stroke is likely to occur in patients with a restricted cerebral blood flow reserve. Our aims were todetermine (1) whether symptomatic patients had any significant hemodynamic restriction ipsilateral to carotid occlusive disease compared with patients whose carotid stenosis is asymptomatic and (2) whether patients with carotid occlusive disease have impaired cerebral perfusion reserve compared with control subjects. Methods We compared cerebral blood flow and collateral capacity using the Xe-133 inhalation method and acetazolamide test in symptomatic (n=10) and asymptomatic (n=10) patients who had a high-grade internal carotid artery stenosis (range, 70% to 99%). Results were compared with those from 10 healthy control subjects. Results Mean baseline cerebral blood flow was 40.29+/-1.38 mL/100 g per minute on the symptomatic side in symptomatic patients versus 45.20+/-2.53 mL/100 g per minute on the lesion side in asymptomaticpatients (control subjects, 46.91+/-2.11 mL/100 g per minute in the right hemisphere versus 46.17+/-1.93 mL/100 g per minute in the left). There was no statistical difference between patients in symptomatic and asymptomatic groups versus control subjects (P>.10). Mean cerebral blood flow increase after acetazolamide was in the same range in symptomatic (52.89+/-2.54 mL/100 g per minute) and asymptomatic (56.22+/-3.35 mL/100 g per minute) patients (P>.10), and no difference was observed regarding control subjects (54.25+/-2.94 mL/100 g per minute; P>.10). Three asymptomatic and two symptomatic patients and three control subjects had no significant cerebral blood flow increase after acetazolamide. Conclusions An additional hemodynamic factor in thromboembolic ischemia related to severe unilateral carotid stenosis might be an unusual finding in patients without apparent hemodynamic induction of symptoms. The lack of significant variation in postacetazolamide cerebral blood flow in some patients and control subjects implies that this procedure may be inconsistent in assessing the cerebral perfusion reservein the individual case.

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Documento generato il 18/09/20 alle ore 19:23:47