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Titolo:
ROLE OF ANGIOTENSINOGEN IN THE GENETICS OF ESSENTIAL-HYPERTENSION
Autore:
HATA A;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PUBL HLTH,N15,W7 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Life sciences
fascicolo: 26, volume: 57, anno: 1995,
pagine: 2385 - 2395
SICI:
0024-3205(1995)57:26<2385:ROAITG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; HUMAN RENIN; TRANSGENIC MICE; RATS; SUBSTRATE; IDENTIFICATION; SYSTEM; POLYMORPHISMS; PREECLAMPSIA; INCREASE;
Keywords:
ANGIOTENSINOGEN; ESSENTIAL HYPERTENSION; SIB PAIR METHOD; GENETICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
A. Hata, "ROLE OF ANGIOTENSINOGEN IN THE GENETICS OF ESSENTIAL-HYPERTENSION", Life sciences, 57(26), 1995, pp. 2385-2395

Abstract

Although essential hypertension has long been recognized to involve astrong genetic predisposition, the genes that increase susceptibilityremain virtually unknown. With recent advances in molecular biology and statistical methods, it has become feasible to study candidate genes which may contribute to the pathogenesis of essential hypertension in humans. Recently, the angiotensinogen (AGT) locus was demonstrated to exhibit genetic linkage and association to essential hypertension and to preeclampsia. While the statistical evidence that mutations of the AGT gene or a neighboring gene contribute to the development of hypertension is strong, the exact mechanism(s) by which these mutations affect the regulation of blood pressure (BP) is unknown. Increasing attention is now being focused on elucidating this mechanism(s).

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Documento generato il 17/01/21 alle ore 17:24:41