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Titolo:
EFFECT OF CALCIUM-CHANNEL BLOCKERS ON NOREPINEPHRINE RELEASE AND MODULATION BY PREJUNCTIONAL D-2 DOPAMINE-RECEPTORS
Autore:
FRIEDMAN DJ; DUCKLES SP;
Indirizzi:
UNIV CALIF IRVINE,CALIF COLL MED,DEPT PHARMACOL IRVINE CA 92717 UNIV CALIF IRVINE,CALIF COLL MED,DEPT PHARMACOL IRVINE CA 92717
Titolo Testata:
Life sciences
fascicolo: 21, volume: 54, anno: 1994,
pagine: 1545 - 1557
SICI:
0024-3205(1994)54:21<1545:EOCBON>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEGA-CONOTOXIN GVIA; RAT LACTOTROPH CELLS; SYMPATHETIC NEURONS; NORADRENALINE RELEASE; NEUROTRANSMITTER RELEASE; ALPHA-ADRENOCEPTORS; MEDIATED MODULATION; TRANSMITTER RELEASE; PERIPHERAL NEURONS; SENSORY NEURONS;
Keywords:
NOREPINEPHRINE; CALCIUM CHANNELS; D-2 DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Friedman e S.P. Duckles, "EFFECT OF CALCIUM-CHANNEL BLOCKERS ON NOREPINEPHRINE RELEASE AND MODULATION BY PREJUNCTIONAL D-2 DOPAMINE-RECEPTORS", Life sciences, 54(21), 1994, pp. 1545-1557

Abstract

Influx of calcium through voltage-dependent N-type calcium channels promotes the release of norepinephrine from nerve terminals. Contributions by L- and N-type calcium channels at different levels of nerve stimulation were examined in perfused rat tail arteries loaded with [H-3]norepinephrine. Nifedipine had no effect while omega-conotoxin reducedtritium efflux by 69 to 82% depending on the stimulation intensity. Thus, N-type calcium channels predominated in the control of norepinephrine release, and the relative contribution of L- and N-type channels did not change when stimulation intensity was altered. We also explored the effect of calcium channel blockers on modulation of norepinephrine release by D-2 dopamine receptors. Inhibition of stimulation-evokedtritium efflux by the D-2 agonist N-0923 was similar in the absence and presence of nifedipine and/or omega-conotoxin. We conclude that D-2dopamine receptors are not coupled to L-type calcium channels; however, the role of N-type calcium channels requires further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:58:42