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Titolo:
HUMAN RECOMBINANT FOLLISTATIN-288 SUPPRESSES PLASMA-CONCENTRATIONS OFFOLLICLE-STIMULATING-HORMONE BUT IS NOT A SIGNIFICANT REGULATOR OF LUTEINIZING-HORMONE IN CASTRATED RAMS
Autore:
TILBROOK AJ; CLARKE IJ; DEKRETSER DM;
Indirizzi:
MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,INST REPROD & DEV CLAYTON VIC 3168 AUSTRALIA PRINCE HENRYS INST MED RES CLAYTON VIC 3168 AUSTRALIA
Titolo Testata:
Biology of reproduction
fascicolo: 6, volume: 53, anno: 1995,
pagine: 1353 - 1358
SICI:
0006-3363(1995)53:6<1353:HRFSPO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; MONKEY MACACA-MULATTA; BETA MESSENGER-RNA; PULSATILE SECRETION; OVARIECTOMIZED EWES; PULSE FREQUENCY; INHIBIN-A; FSH; PITUITARY; TESTOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Tilbrook et al., "HUMAN RECOMBINANT FOLLISTATIN-288 SUPPRESSES PLASMA-CONCENTRATIONS OFFOLLICLE-STIMULATING-HORMONE BUT IS NOT A SIGNIFICANT REGULATOR OF LUTEINIZING-HORMONE IN CASTRATED RAMS", Biology of reproduction, 53(6), 1995, pp. 1353-1358

Abstract

We have tested the hypothesis that treatment of castrated rams (wethers) with human recombinant follistatin-288 (FS-288) suppresses plasma concentrations of FSH but has no effect on plasma concentrations of LH. Wethers were given an i.v. injection of vehicle or 50 mu g F5-288 followed by a 12-h i.v. infusion of vehicle or 800 mu g FS-288, respectively. This dose and treatment regimen was identical to that used in a previous study in which wethers were treated with vehicle or human recombinant inhibin A (hr-inhibin). Human recombinant follistatin significantly (p < 0.05) suppressed plasma concentrations of FSH, but vehiclehad no effect. The maximal suppression of FSH occurred 12-15 h after the start of treatment, at which time the plasma concentrations were reduced by 20.6%. The reduction in plasma concentrations of FSH caused by 88-288 was about 2.5-fold less than that observed after the same treatment with hr-inhibin. FS-288 had no effect on plasma concentrationsof LH; this result was similar to the findings we obtained with hr-inhibin. These data suggest that follistatin is a less potent negative regulator of FSH secretion than inhibin and that follistatin is not a significant regulator of the secretion of LH in rams.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:23:10