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Titolo:
MYOGENESIS IN PARAXIAL MESODERM - PREFERENTIAL INDUCTION BY DORSAL NEURAL-TUBE AND BY CELLS EXPRESSING WNT-1
Autore:
STERN HM; BROWN AMC; HAUSCHKA SD;
Indirizzi:
UNIV WASHINGTON,DEPT BIOCHEM,BOX 357350 SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOCHEM SEATTLE WA 98195 CORNELL UNIV,COLL MED,DEPT CELL BIOL & ANAT NEW YORK NY 10021 CORNELL UNIV,COLL MED,STRANG CORNELL CANC RES LAB NEW YORK NY 10021
Titolo Testata:
Development
fascicolo: 11, volume: 121, anno: 1995,
pagine: 3675 - 3686
SICI:
0950-1991(1995)121:11<3675:MIPM-P>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; NERVOUS-SYSTEM; CHICK-EMBRYO; TERMINAL DIFFERENTIATION; MUSCLE DIFFERENTIATION; VERTEBRATE MYOGENESIS; INT-1 PROTOONCOGENE; CLONAL ANALYSIS; FLOOR PLATE; LIMB BUD;
Keywords:
SOMITE; NEURAL TUBE; NOTOCHORD; WNT; MYOGENESIS; INDUCTION; CHICK EMBRYO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Stern et al., "MYOGENESIS IN PARAXIAL MESODERM - PREFERENTIAL INDUCTION BY DORSAL NEURAL-TUBE AND BY CELLS EXPRESSING WNT-1", Development, 121(11), 1995, pp. 3675-3686

Abstract

Previous studies have demonstrated that the neural tube/notochord complex is required for skeletal muscle development within somites. In order to explore the localization of myogenic inducing signals within the neural tube, dorsal or ventral neural tube halves were cultured in contact with single somites or pieces of segmental plate mesoderm. Somites and segmental plates cultured with the dorsal half of the neural tube exhibited 70% and 85% myogenic response rates, as determined by immunostaining for myosin heavy chain, This response was slightly lower than the 100% response to whole neural tube/notochord, but was much greater than the 30% and 10% myogenic response to ventral neural tube with and without notochord. These results demonstrate that the dorsal neural tube emits a potent myogenic inducing signal which accounts for most of the inductive activity of whole neural tube/notochord. However,a role for ventral neural tube/notochord in somite myogenic inductionwas clearly evident from the larger number of myogenic cells induced when both dorsal neural tube and ventral neural tube/notochord were present. To address the role of a specific dorsal neural tube factor in somite myogenic induction, we tested the ability of Wnt-1-expressing fibroblasts to promote paraxial mesoderm myogenesis in vitro. We found that cells expressing Wnt-1 induced a small number of somite and segmental plate cells to undergo myogenesis. This finding is consistent with the localized dorsal neural tube inductive activity described above,but since the ventral neural tube/notochord also possesses myogenic inductive capacity yet does not express Wnt-1, additional inductive factors are likely involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:45:16