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Titolo:
CONTRIBUTION TO CHARACTERIZATION OF ANORECTIC PROTEIN SIMILAR TO SATIETIN FROM URINE
Autore:
MALETINSKA L; SLANINOVA J;
Indirizzi:
ACAD SCI CZECH REPUBL,INST ORGAN CHEM & BIOCHEM,FLEMINGOVO NAM 2 CR-16610 PRAGUE 6 CZECH REPUBLIC ACAD SCI CZECH REPUBL,INST ORGAN CHEM & BIOCHEM CR-16610 PRAGUE 6 CZECH REPUBLIC
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 52, anno: 1995,
pagine: 715 - 721
SICI:
0091-3057(1995)52:4<715:CTCOAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANOREXIGENIC PROTEIN; FOOD-INTAKE; CHOLECYSTOKININ; RAT; PROTEOGLYCAN; INFUSION; PEPTIDES;
Keywords:
ANORECTIC SUBSTANCE; RAT URINE; ANOREXIA; SATIETY; MICE; GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L. Maletinska e J. Slaninova, "CONTRIBUTION TO CHARACTERIZATION OF ANORECTIC PROTEIN SIMILAR TO SATIETIN FROM URINE", Pharmacology, biochemistry and behavior, 52(4), 1995, pp. 715-721

Abstract

An anorectic substance similar to satietin was purified from ethanolic-acid precipitate of rat urine by gel filtration and ion exchange chromatography. The obtained glycoprotein (molecular mass 67 kDa) reducedfood intake after intraperitoneal and intracisternal administration in mice in a dose-dependent manner (in the range of 5-80 mg/kg). The anorectic effect was specific. In the presence of sodium dodecylsulphatethe substance dissociated into small proteins with a molecular mass of 9-11 kDa. Its anorectic effect was long lasting and differed from that of the anorectic peptide cholecystokinin octapeptide. Our finding supports the idea that anorectic protein isolated from plasma, membranes, and urine may be related substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:58:41