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Titolo:
PEPTIDES AS NEUROTRANSMITTERS IN VASCULAR AUTONOMIC NEURONS
Autore:
MORRIS JL;
Indirizzi:
FLINDERS MED CTR,DEPT ANAT & HISTOL BEDFORD PK SA 5042 AUSTRALIA FLINDERS UNIV S AUSTRALIA,SCH MED,DEPT ANAT & HISTOL ADELAIDE SA 5001AUSTRALIA FLINDERS UNIV S AUSTRALIA,SCH MED,CTR NEUROSCI ADELAIDE SA 5001 AUSTRALIA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 11, volume: 22, anno: 1995,
pagine: 792 - 802
SICI:
0305-1870(1995)22:11<792:PANIVA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; PIG UTERINE ARTERY; GENE-RELATED PEPTIDE; NEUROPEPTIDE-Y RECEPTOR; CYCLASE-ACTIVATING POLYPEPTIDE; DOPAMINE-BETA-HYDROXYLASE; NON-NORADRENERGIC AXONS; CARDIAC VAGAL ACTION; RAT TAIL ARTERY; GUINEA-PIG;
Keywords:
AUTONOMIC NEURONS; COTRANSMISSION; NEUROPEPTIDE; NEUROTRANSMITTER; VASOCONSTRICTION; VASODILATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
118
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Morris, "PEPTIDES AS NEUROTRANSMITTERS IN VASCULAR AUTONOMIC NEURONS", Clinical and experimental pharmacology and physiology, 22(11), 1995, pp. 792-802

Abstract

1. Neuropeptides are present in the majority of autonomic neurons projecting to blood vessels, where they are co-localized with non-peptidetransmitters and sometimes with other peptides. 2. Neuropeptides are released from vasoconstrictor and vasodilator nerve terminals after high frequency stimulation (> 2-5 Hz) with trains of impulses. 3. Neuropeptides can have potent post-synaptic effects on vascular tone, but often these effects are restricted to selected regions of the vasculature. 4. Post-synaptic effects of neuropeptides tend to be more slowly-developing and more long-lasting than those of non-peptide transmitters.5. Autonomic vasoconstrictor and vasodilator responses often have multiple phases, with the faster phases being mediated by non-peptide transmitters and the slower phases mediated predominantly by one or more neuropeptides. 6. Some neuropeptides do not seem to have post-synapticeffects in a particular vascular bed, but can have presynaptic actions on neurotransmitter release. 7. Neuropeptides form an important component of the repertoire of neurotransmitters used by vascular autonomic neurons to regulate regional blood now in response to a range of physiological stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:34:56