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Titolo:
LUNG-TUMOR GROWTH CORRELATES WITH GLUCOSE-METABOLISM MEASURED BY FLUORIDE-18 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY
Autore:
DUHAYLONGSOD FG; LOWE VJ; PATZ EF; VAUGHN AL; COLEMAN E; WOLFE WG;
Indirizzi:
DUKE UNIV,MED CTR,DEPT SURG,POB 3507 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT SURG DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT RADIOL DURHAM NC 27710
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 5, volume: 60, anno: 1995,
pagine: 1348 - 1352
SICI:
0003-4975(1995)60:5<1348:LGCWGM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLITARY PULMONARY NODULES; BRONCHOGENIC-CARCINOMA; PROLIFERATIVE ACTIVITY; NEEDLE ASPIRATION; CANCER; INVIVO; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
F.G. Duhaylongsod et al., "LUNG-TUMOR GROWTH CORRELATES WITH GLUCOSE-METABOLISM MEASURED BY FLUORIDE-18 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY", The Annals of thoracic surgery, 60(5), 1995, pp. 1348-1352

Abstract

Background. The growth rate, or doubling time, of radiographically indeterminate pulmonary abnormalities is an important determinant of malignancy. Prospective calculation of doubling time, however, delays diagnosis and treatment. Positron emission tomography (PET) using the glucose analogue fluoride-18 fluorodeoxyglucose (FDG) measures the enhanced glucose uptake characteristic of neoplastic cells. We postulated that if FDG activity correlates with doubling time, then PET may allow prompt diagnosis of lung cancer. Methods. From March 1992 to July 1993,all patients with indeterminate focal pulmonary abnormalities were eligible for FDG PET imaging. In 53 patients, serial chest radiographs or computed tomograms were available and doubling time was computed. The FDG activity within the lesion was expressed as a standardized uptake ratio. Results. The mean standardized uptake ratio (+/- SD) was 5.9 /- 2.7 in 34 patients with cancer, versus 2.0 +/- 1.7 in 19 with benign disease (p < 0.001). Using a criterion of standardized uptake ratio2.5 or greater for malignancy, the accuracy of PET was 92% (49 of 53). The standardized uptake ratio was significantly correlated with doubling time (r = -0.89; p = 0.002). Conclusion. These data suggest a direct relation between tumor growth and FDG uptake in lung cancer. The technique of FDG PET demonstrates exceptional accuracy and may permit prompt diagnosis of lung cancer.

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Documento generato il 20/01/21 alle ore 05:52:16