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Titolo:
BENZODIAZEPINES FOR INSOMNIA IN COMMUNITY-DWELLING ELDERLY - A REVIEWOF BENEFIT AND RISK
Autore:
GRAD RM;
Indirizzi:
HERZL FAMILY PRACTICE CTR,5757 RUE LEGARE MONTREAL PQ H3T 1Z6 CANADA MCGILL UNIV,DEPT FAMILY MED MONTREAL PQ H3A 2T5 CANADA
Titolo Testata:
Journal of family practice
fascicolo: 5, volume: 41, anno: 1995,
pagine: 473 - 481
SICI:
0094-3509(1995)41:5<473:BFIICE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERIATRIC-PATIENTS; HIP FRACTURE; DRUG-USE; FLURAZEPAM; TRIAZOLAM; SLEEP; HYPNOTICS; PERFORMANCE; EFFICACY; LONG;
Keywords:
INSOMNIA; AGED; BENZODIAZEPINES; ANTI-ANXIETY AGENTS, BENZODIAZEPINE; AMBULATORY CARE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Grad, "BENZODIAZEPINES FOR INSOMNIA IN COMMUNITY-DWELLING ELDERLY - A REVIEWOF BENEFIT AND RISK", Journal of family practice, 41(5), 1995, pp. 473-481

Abstract

To critically assess and summarize the beneficial effects of benzodiazepine therapy for insomnia in community-dwelling elders, a systematicsearch was undertaken to review all published clinical trials and sleep laboratory studies. The risk of injury for benzodiazepine users wasalso reviewed. Ten studies met inclusion criteria for assessing benefit. There are no studies regarding the long-term effectiveness of benzodiazepines for the treatment of sleep disorders in the elderly. In the sleep laboratory setting, triazolam 0.125 mg, flurazepam 15 mg, and estazolam 1 mg improved sleep latency by 27 to 30 minutes and increased total sleep time by 47 to 81 minutes for the first 2 to 3 nights of treatment, compared with baseline measurements taken while the patients were receiving placebo. In contrast to these, modest short-term benefits, there is an association between the use of benzodiazepines with a long half-life, eg, flurazepam, diazepam, and chlordiazepoxide, and an increased risk of hip fracture in the elderly. Triazolam can cause rebound insomnia as well as anterograde. Clinicians should discontinuetheir prescribing of long-acting benzodiazepines for elderly patientswith insomnia. More research is needed on the effects of nondrug interventions as well as on short- and intermediate acting benzodiazepines, such as oxazepam and temazepam, to treat insomnia in community-dwelling elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:41:40