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Titolo:
ANATOMICAL PLASTICITY IN THE MEDIAL SUPERIOR OLIVE FOLLOWING ABLATIONOF THE INFERIOR COLLICULUS IN NEONATAL AND ADULT-RATS
Autore:
OKOYAMA S; MORIIZUMI T; KITAO Y; KAWANO J; KUDO M;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT ANAT KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT ANAT KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 88, anno: 1995,
pagine: 71 - 78
SICI:
0378-5955(1995)88:1-2<71:APITMS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; COCHLEAR NUCLEUS; EARLY LESIONS; PROJECTIONS; NEURONS; MONKEYS; REMOVAL; DEATH;
Keywords:
INFERIOR COLLICULUS; MEDIAL SUPERIOR OLIVE; ABERRANT PROJECTION; RETROGRADE CELL DEGENERATION; PLASTICITY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Okoyama et al., "ANATOMICAL PLASTICITY IN THE MEDIAL SUPERIOR OLIVE FOLLOWING ABLATIONOF THE INFERIOR COLLICULUS IN NEONATAL AND ADULT-RATS", Hearing research, 88(1-2), 1995, pp. 71-78

Abstract

We evaluated the consequences of unilateral ablation of the inferior colliculus (IC) upon the ascending projection from the medial superiorolive (MSG) to the IC. Ablation of the IC was performed in rats aged between postnatal day 1 (P1) and maturity. All the rats were given injections of Fluoro-Gold (FG) into the ipsilateral IC at birth (PO) (before the ipsilateral IC was ablated in any case) so that growth of early-developing axons to the ipsilateral IC could be examined for any labeled neurons in the ipsilateral MSG. Upon reaching adulthood, the ratsreceived injections of Fluoro-Ruby (FR) into the contralateral (intact) IC so that aberrant crossed projections to the intact IC could be examined for any labeled neurons in the ipsilateral MSG. These rats were killed 2 days after FR injections. The number of surviving cells in the ipsilateral MSO were counted in Nissl-stained sections for quantitative analysis of retrograde degeneration. The results show that: (1) the total number of neurons was reduced to 64-34% in the ipsilateral MSO as a result of IC ablation; (2) cell reduction by retrograde degeneration followed a U-shaped curve with a maximal effect in rats operated at P7 (reduced to 34%); (3) adult ablation of the IC led to retrograde degeneration that was less severe than that in late neonatal (P7) ablation; (4) an aberrant projection from the MSO to the contralateral IC occurred in rats operated at P1 and P3 but not in rats operated at P7 or maturity. Thus, our findings suggest that growth of late-developing axons is a major factor in the plasticity of this system of projection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:01:21