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Titolo:
AN ASTROCYTIC BINDING-SITE FOR NEURONAL THY-1 AND ITS EFFECT ON NEURITE OUTGROWTH
Autore:
DREYER EB; LEIFER D; HENG JE; MCCONNELL JE; GORLA M; LEVIN LA; BARNSTABLE CJ; LIPTON SA;
Indirizzi:
MASSACHUSETTS EYE & EAR INFIRM,HOWE LAB BOSTON MA 02114 MASSACHUSETTS EYE & EAR INFIRM,HOWE LAB BOSTON MA 02114 HARVARD UNIV,CHILDRENS HOSP,SCH MED,MOLEC & CELLULAR NEUROSCI LAB BOSTON MA 02115 HARVARD UNIV,SCH MED,NEUROSCI PROGRAM BOSTON MA 02115 YALE UNIV,SCH MED NEW HAVEN CT 06510 UNIV WISCONSIN,SCH MED MADISON WI 53792
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 24, volume: 92, anno: 1995,
pagine: 11195 - 11199
SICI:
0027-8424(1995)92:24<11195:AABFNT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; ADHESION MOLECULES; IMMUNOGLOBULIN SUPERFAMILY; ENHANCES REGENERATION; SURFACE GLYCOPROTEIN; ANTIBODIES; CULTURE; MEMBER; GENE; EXPRESSION;
Keywords:
NEURONAL REGENERATION; NEURONAL DEVELOPMENT; IMMUNOGLOBULIN SUPERFAMILY; MONOCLONAL ANTIIDIOTYPE ANTIBODIES; ASTROCYTE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Dreyer et al., "AN ASTROCYTIC BINDING-SITE FOR NEURONAL THY-1 AND ITS EFFECT ON NEURITE OUTGROWTH", Proceedings of the National Academy of Sciences of the United Statesof America, 92(24), 1995, pp. 11195-11199

Abstract

Thy-1, a member of the immunoglobulin superfamily, is one of the mostabundant glycoproteins on mammalian neurons. Nevertheless, its role in the peripheral or central nervous system is poorly understood. Certain monoclonal antibodies to Thy-1 promote neurite outgrowth by rodent central nervous system neurons in vitro, suggesting that Thy-1 functions, in part, by modulating neurite outgrowth. We describe a binding site for Thy-1 on astrocytes. This Thy-1-binding protein has been characterized by immunofluorescence with specific anti-idiotype monoclonal antibodies and by three competitive binding assays using (i) anti-idiotype antibodies, (ii) purified Thy-1, and (iii) Thy-1 transfected cells. The Thy-1-binding protein may participate in axonal or dendritic development in the nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:15:55