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Titolo:
NO RELATION OF PLASMA MORPHINE LEVEL TO THE SEVERITY OF NALOXONE-INDUCED WITHDRAWAL IN ACUTE MORPHINE-DEPENDENT RATS
Autore:
KISHIOKA S; INOUE N; NISHIDA S; FUKUNAGA Y; YAMAMOTO H;
Indirizzi:
WAKAYAMA MED COLL,DEPT PHARMACOL,9 BANCHO 27 WAKAYAMA 640 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 3, volume: 69, anno: 1995,
pagine: 187 - 193
SICI:
0021-5198(1995)69:3<187:NROPML>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE;
Keywords:
INTRAVENOUS MORPHINE INFUSION; PLASMA MORPHINE CONCENTRATION; NALOXONE-WITHDRAWAL; BODY WEIGHT LOSS; PLASMA CORTICOSTERONE INCREASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S. Kishioka et al., "NO RELATION OF PLASMA MORPHINE LEVEL TO THE SEVERITY OF NALOXONE-INDUCED WITHDRAWAL IN ACUTE MORPHINE-DEPENDENT RATS", Japanese Journal of Pharmacology, 69(3), 1995, pp. 187-193

Abstract

Plasma morphine concentration and naloxone-precipitated withdrawal body weight loss and plasma corticosterone (PCS) increase were determined at 12, 18 and 24 hr after i.v. infusion of morphine at a constant rate of 10 mg/kg/hr for 4 hr in Sprague-Dawley rats. Plasma morphine concentration declined 98.0% within 12 hr and further declined 58.8% during 12-24 hr after morphine infusion. There was a significant difference between plasma morphine concentrations at 12 and 24 hr after the morphine infusion. Naloxone (0.5 and 2.0 mg/kg)-precipitated withdrawal, but not spontaneous withdrawal, was elicited at 12-24 hr after the morphine infusion, and the severity of withdrawal precipitated by 2.0 mg/kg naloxone was the same at 12-24 hr after the morphine infusion. Furthermore, there was no significant correlation between plasma morphine concentration and body weight loss or PCS increase. The results suggest that a constant degree of morphine dependence is sustained during 12-24 hr after the morphine infusion and the severity of naloxone-precipitated withdrawal is not related to the plasma morphine concentration at the time of naloxone injection, that is, the rate of morphine removal from its receptor sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 17:34:29