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Titolo:
PLASMA ANP AND CYCLIC-GMP LEVELS VERSUS LEFT-VENTRICULAR PERFORMANCE AT DIFFERENT AV DELAYS IN AV SEQUENTIAL PACING
Autore:
SURDACKI A; BEDNAREK T; RADZISZEWSKI W; SZCZEPKOWSKI J; DUBIEL JS; RUSKOAHO H; SEDZIWY L; WIECZOREK E;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT CARDIOL 2,17 KOPERNIKA ST PL-31501 KRAKOW POLAND JAGIELLONIAN UNIV,COLL MED,DEPT ELECTROCARDIOL KRAKOW POLAND JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL KRAKOW POLAND UNIV OULU,DEPT PHARMACOL & TOXICOL OULU FINLAND
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 4, volume: 17, anno: 1994,
parte:, 1
pagine: 627 - 636
SICI:
0147-8389(1994)17:4<627:PAACLV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; DIASTOLIC MITRAL REGURGITATION; ATRIOVENTRICULAR-CONDUCTION ABNORMALITIES; DUAL-CHAMBER PACEMAKERS; DOPPLER ECHOCARDIOGRAPHY; PULSED DOPPLER; HEMODYNAMIC-CHANGES; CARDIAC-OUTPUT; HEART-DISEASE; FLOW VELOCITY;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; CYCLIC GMP; DDD PACING HEMODYNAMICS; ATRIOVENTRICULAR INTERVAL;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
A. Surdacki et al., "PLASMA ANP AND CYCLIC-GMP LEVELS VERSUS LEFT-VENTRICULAR PERFORMANCE AT DIFFERENT AV DELAYS IN AV SEQUENTIAL PACING", PACE, 17(4), 1994, pp. 627-636

Abstract

Eleven resting patients with an implanted DDD pacemaker were studied. After 30 minutes of Av sequential pacing at a rate of 80 beats/min with three consecutive atrioventricular delays (AVDs; 100, 150, and 200 msec) peripheral venous blood was drawn for further analyses by specific radioimmunoassays of atrial natriuretic peptide (ANP) and the ANP second messenger, cyclic guanosine monophosphate (cGMP). Relative changes in left ventricular (LV) stroke volume following alterations of AVDwere assessed by means of pulsed-Doppler echocardiography through measurement of LV outflow time-velocity integrals (TVI). The optimal AVD (oAVD) was defined in individual patients as that which was associatedwith the greatest TVI and with improvement over both other AVDs of more than 4%. The oAVD was found in nine patients. For these nine patients no significant differences in either plasma ANP or cGMP between various AVDs were observed. However, we found such differences with respect to values measured at oAVD; both ANP and cGMP levels were lowest atoAVD. Pooling together the data obtained in 11 patients at three AVDs, a positive correlation between ANP and cGMP levels was found (r = 0.7, P < 0.0001, n = 33). Moreover, changes of plasma ANP and cGMP induced by every AVD increment of 50 msec were also correlated (r = 0.6, P < 0.01, n = 22). It is concluded that in AV sequential pacing at rest plasma ANP reaches minimal levels at the AVD, which provides the best LV performance. Although levels of cGMP changed in parallel with thoseof ANP, low relative values of cGMP differences may limit the usefulness of cGMP assays in optimization of the AVD.

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Documento generato il 27/11/20 alle ore 02:06:24