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Titolo:
NEUTRALIZING ANTIBODIES IN SLOWLY PROGRESSING HIV-1 INFECTION
Autore:
SCHONNING K; NIELSEN C; IVERSEN J; NIELSEN JO; HANSEN JES;
Indirizzi:
HVIDOVRE UNIV HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK HVIDOVRE UNIV HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK STATE SERUM INST,DEPT VIROL,RETROVIRUS LAB COPENHAGEN DENMARK
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 4, volume: 10, anno: 1995,
pagine: 400 - 407
SICI:
1077-9450(1995)10:4<400:NAISPH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; AIDS-RELATED COMPLEX; PROGNOSTIC VALUE; TYPE-1; HTLV; LYMPHOCYTES; RETROVIRUS; PHENOTYPE; DISEASE;
Keywords:
HIV-1; SLOW PROGRESSION; NEUTRALIZING ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Schonning et al., "NEUTRALIZING ANTIBODIES IN SLOWLY PROGRESSING HIV-1 INFECTION", Journal of acquired immune deficiency syndromes and human retrovirology, 10(4), 1995, pp. 400-407

Abstract

Ten asymptomatic individuals who had experienced only limited CD4(+) cell loss after prolonged infection with HIV-1 were studied. These individuals had a mean CD4(+) cell count of 674 x 10(6) cells/L and a mean duration of infection of 8.5 years, Also included were 10 asymptomatic HIV-1-infected individuals who, over a similar period of infection (7.5 years), had experienced a profound loss of CD4(+) cells (mean CD4(+) cell count, 54 x 10(6) cells/L). Proviral load was determined using a semiquantitative polymerase chain reaction and was significantly lower in the subjects with slowly progressing infection (SPI) than in subjects with rapidly progressing infection (RPI) (4,000 vs. 40,000 proviral copies/10(6) peripheral blood mononuclear cells; p = 0.0089), Isolation of virus was attempted in all individuals but succeeded only in 6 of 10 individuals with SPI versus all 10 individuals with RPI. Four of six virus isolates obtained from individuals with SPI and 6 of 10obtained from individuals with RPI were of the syncytia-inducing phenotype. We determined the neutralizing activity of serum against HIVMN,HIVIIIB, and the contemporaneous autologous isolate when available. Serum from individuals with SPI generally neutralized the contemporaneous isolate, whereas serum from individuals with RPI did not [geometricmean antibody titer (GMT), 45 vs, 3; p = 0.0047]. There was no difference in neutralizing ability against HIVMN (GMT,2,593 vs. 2,263; p = 0.74) and only a small difference against HIVIIIB (GMT, 115 vs. 50; p =0.075). Our results indicate that individuals with SPI are characterized by an ability to neutralize their own HIV strain. In contrast, neutralizing activity against HIVMN and HIVIIIB did not distinguish individuals with SPI from individuals with RPI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:33:28