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Titolo:
ALTERATIONS OF LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE PROTEIN LEVEL INALZHEIMERS-DISEASE
Autore:
SHIMOHAMA S; FUJIMOTO S; CHACHIN M; TANIGUCHI T; PERRY G; WHITEHOUSE PJ; KIMURA J;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT NEUROL,SAKYO KU,54 SHOGOIN KAWAHARACHO KYOTO 606 JAPAN KYOTO PHARMACEUT UNIV,DEPT BIOCHEM KYOTO 607 JAPAN KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL KYOTO 607 JAPAN CASE WESTERN RESERVE UNIV,INST PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROL CLEVELAND OH 44106
Titolo Testata:
Brain research
fascicolo: 1, volume: 699, anno: 1995,
pagine: 125 - 129
SICI:
0006-8993(1995)699:1<125:AOLAPL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE PHOSPHORYLATION; BRAIN;
Keywords:
ACID PHOSPHATASE; LOW MOLECULAR WEIGHT; ANTIBODY; PROTEIN LEVEL; ACTIVITY; ALZHEIMERS DISEASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
S. Shimohama et al., "ALTERATIONS OF LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE PROTEIN LEVEL INALZHEIMERS-DISEASE", Brain research, 699(1), 1995, pp. 125-129

Abstract

We have previously reported that the activity of low molecular weight(LMW) acid phosphatase, which can remove tyrosine-linked phosphates of epidermal growth factor receptor, was significantly decreased in Alzheimer brains. In the present study, a specific antibody was prepared to analyze the protein lever of this enzyme. Western blot analysis indicated that the level of LMW acid phosphatase protein was significantly reduced, whereas the activity of LMW acid phosphatase per enzyme molecule was not changed in Alzheimer brains. These results suggest that the reduction of LMW acid phosphatase activity in Alzheimer brains is due to its decreased protein level in Alzheimer's disease.

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Documento generato il 25/09/20 alle ore 21:14:58