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Titolo:
THE PERIPHERAL CANNABINOID RECEPTOR - ADENYLATE-CYCLASE INHIBITION AND G-PROTEIN COUPLING
Autore:
BAYEWITCH M; AVIDORREISS T; LEVY R; BARG J; MECHOULAM R; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL THERAPEUT COMMUNITY ZOHARIM ISRAEL HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD IL-91010 JERUSALEM ISRAEL
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 375, anno: 1995,
pagine: 143 - 147
SICI:
0014-5793(1995)375:1-2<143:TPCR-A>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED SIGNAL-TRANSDUCTION; ANANDAMIDE; BRAIN; CELLS; MODULATION; EXPRESSION; AGONIST; BINDS;
Keywords:
ADENYLATE CYCLASE; ANANDAMIDE; CANNABINOID RECEPTOR; DELTA(9)-TETRAHYDROCANNABINOL; GTP-BINDING PROTEINS; TRICYCLIC CANNABINOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Bayewitch et al., "THE PERIPHERAL CANNABINOID RECEPTOR - ADENYLATE-CYCLASE INHIBITION AND G-PROTEIN COUPLING", FEBS letters, 375(1-2), 1995, pp. 143-147

Abstract

Two cannabinoid receptors, designated neuronal (or CB1) and peripheral (or CB2), have recently been cloned, Activation of CB1 receptors leads to inhibition of adenylate cyclase and N-type voltage-dependent Ca2 channels, Here we show, using a CB2 transfected Chinese hamster ovary cell line, that this receptor binds a variety of tricyclic cannabinoid ligands as well. as the endogenous ligand anandamide, Activation ofthe CB2 receptor by various tricyclic cannabinoids inhibits adenylatecyclase activity and this inhibition is pertussis toxin sensitive indicating that this receptor is coupled to the G(i)/G(o) GTP-binding proteins, Interestingly, contrary to results with CB1, anandamide did notinhibit the CB2 coupled adenylate cyclase activity and Delta(9)-tetrahydrocannabinol had only marginal effects, These results characterize the CB2 receptor as a functional and distinctive member of the cannabinoid receptor family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:48:57