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Titolo:
FORMATION OF NORMAL GINGIVAL EPITHELIAL PHENOTYPES AROUND OSSEOINTEGRATED ORAL IMPLANTS IN HUMANS
Autore:
MACKENZIE IC; TONETTI MS;
Indirizzi:
UNIV MICHIGAN,SCH DENT,2361 DENT 1078 ANN ARBOR MI 48109 UNIV TEXAS,HLTH SCI CTR,DENT BRANCH HOUSTON TX 77225 UNIV BERN,SCH DENT MED,DEPT PERIODONTOL & FIXED PROSTHODONT BERN SWITZERLAND
Titolo Testata:
Journal of periodontology
fascicolo: 11, volume: 66, anno: 1995,
pagine: 933 - 943
SICI:
0022-3492(1995)66:11<933:FONGEP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-GROUP ANTIGEN; CYTOKERATIN EXPRESSION; JUNCTIONAL EPITHELIUM; CELL-PROLIFERATION; DIFFERENTIATION; PATTERNS; GROWTH; SKIN; ICAM-1; MUCOSA;
Keywords:
DENTAL IMPLANTS; GINGIVA ANATOMY AND HISTOLOGY; EPITHELIUM ANATOMY AND HISTOLOGY; KERATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
I.C. Mackenzie e M.S. Tonetti, "FORMATION OF NORMAL GINGIVAL EPITHELIAL PHENOTYPES AROUND OSSEOINTEGRATED ORAL IMPLANTS IN HUMANS", Journal of periodontology, 66(11), 1995, pp. 933-943

Abstract

THE ORAL, ORAL SULCULAR, AND JUNCTIONAL epithelia of the natural gingiva each possess distinct patterns of differentiation that are demonstrable both ultrastructurally and by their individual patterns of macromolecular synthesis. The supracrestal tissues reformed around oral implants structurally resemble those of natural gingiva but little is known about phenotypic changes occurring in the epithelia, To investigatewhether peri-implant epithelia acquire similar patterns of differentiation to those of natural gingiva, biopsies from the supracrestal regions of five oral implants were examined by immunofluorescent methods using a panel of monoclonal antibodies with specificities for individual cytokeratins and ICAM-1, macromolecules which act as markers of the three gingival epithelial phenotypes. The observed staining patterns indicated the formation of oral, oral sulcular, and junctional epithelia which were phenotypically indistinguishable from those of natural gingival epithelia. This degree of reprogram ming of epithelial gene expression is a surprising observation and the potential mechanisms leading to the development of those new epithelial phenotypes are discussedin the context of what is known about the development of natural gingiva, in terms of the possible effects of inflammation, and in relationto the known connective tissue influences on epithelial differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 08:40:30