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Titolo:
LATERAL PARABRACHIAL SEROTONERGIC MECHANISMS - ANGIOTENSIN-INDUCED PRESSOR AND DRINKING RESPONSES
Autore:
MENANI JV; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PSYCHOL IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 38, anno: 1995,
pagine: 1044 - 1049
SICI:
0363-6119(1995)38:5<1044:LPSM-A>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EFFERENT CONNECTIONS; ARTERIAL-PRESSURE; URINARY RESPONSES; WATER-INTAKE; NUCLEUS; RAT; LESIONS; PATHWAY;
Keywords:
LATERAL PARABRACHIAL NUCLEUS; ANGIOTENSIN II; WATER INTAKE; ARTERIAL PRESSURE; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Menani e A.K. Johnson, "LATERAL PARABRACHIAL SEROTONERGIC MECHANISMS - ANGIOTENSIN-INDUCED PRESSOR AND DRINKING RESPONSES", American journal of physiology. Regulatory, integrative and comparative physiology, 38(5), 1995, pp. 1044-1049

Abstract

This study investigated the effects of bilateral injections of serotonergic receptor ligands into the lateral parabrachial nucleus (LPBN) on the presser and dipsogenic responses induced by intracerebroventricular (icv) injection of angiotensin II (ANG II). Rats with stainless steel cannulas implanted bilaterally into the LPBN and into the left lateral ventricle were used to study icy ANG II-induced water intake and presser responses. Pretreatment with the serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (1-8 mu g/200 nl) bilaterally injected into the LPBN increased the water intake induced by icv ANG II (50 ng/mul) administered via the lateral ventricle, but pretreatment with methysergide (4 mu g/200 nl) did not change the presser response produced by icy ANG II. After bilateral injection of either serotonin (5-HT, 5 mu g/200 nl) or the serotonergic 5-HT2a/5-HT2c receptor agonist (+/-)-2,5-dimetoxy-4-iodoamphetamine hydrochloride (DOI; 0.5-10 mu g/200 nl)into the LPBN, the water intake induced by ANG II was significantly reduced. These results are consistent with other observations indicating that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II treatment and suggest that serotonergic pathways may be involved in this effect.

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Documento generato il 05/12/20 alle ore 19:54:38