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Titolo:
CIRCADIAN-RHYTHMS OF TEMPERATURE AND ACTIVITY IN OBESE AND LEAN ZUCKER RATS
Autore:
MURAKAMI DM; HORWITZ BA; FULLER CA;
Indirizzi:
UNIV CALIF DAVIS,NEUROBIOL PHYSIOL & BEHAV SECT DAVIS CA 95616 UNIV CALIF DAVIS,NEUROBIOL PHYSIOL & BEHAV SECT DAVIS CA 95616
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 38, anno: 1995,
pagine: 1038 - 1043
SICI:
0363-6119(1995)38:5<1038:COTAAI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETICALLY-OBESE; MEAL PATTERNS; ENERGY-EXPENDITURE; FA/FA RATS; CORTICOSTERONE; HYPERINSULINEMIA; THERMOGENESIS; INSULIN; FATTY;
Keywords:
METABOLISM; ENERGY BALANCE; CIRCADIAN TIMING SYSTEM; SUPRACHIASMATIC NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Murakami et al., "CIRCADIAN-RHYTHMS OF TEMPERATURE AND ACTIVITY IN OBESE AND LEAN ZUCKER RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 38(5), 1995, pp. 1038-1043

Abstract

The circadian timing system is important in the regulation of feedingand metabolism, both of which are aberrant in the obese Zucker rat. This study tested the hypothesis that these abnormalities involve a deficit in circadian regulation by examining the circadian rhythms of body temperature and activity in lean and obese Zucker rats exposed to normal light-dark cycles, constant Light, and constant dark. Significantdeficits in both daily mean and circadian amplitude of temperature and activity were found in obese Zucker female rats relative to lean controls in all lighting conditions. However, the circadian period of obese Zucker rats did not exhibit differences relative to lean controls in either of the constant lighting conditions. These results indicate that although the circadian regulation of temperature and activity in obese Zucker female rats is in fact depressed, obese rats do exhibit normal entrainment and pacemaker functions in the circadian timing system. The results suggest a deficit in the process that generates the amplitude of the circadian rhythm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:21:51