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Titolo:
AUTONOMIC AND VENTILATORY COMPONENTS OF HEART-RATE AND BLOOD-PRESSUREVARIABILITY IN FREELY BEHAVING RATS
Autore:
PERLINI S; GIANGREGORIO F; COCO M; RADAELLI A; SOLDA PL; BERNARDI L; FERRARI AU;
Indirizzi:
UNIV MILAN,CTR FISIOL CLIN & IPERTENS,VIA F SFORZA 35 I-20122 MILAN ITALY UNIV MILAN,CTR FISIOL CLIN & IPERTENS I-20122 MILAN ITALY UNIV PAVIA,DIPARTIMENTO MED INTERNA,MED CLIN 1 I-27100 PAVIA ITALY USSL 30 DESIO,OSPED SEREGNO,DIV CARDIORIABILITAZ MILAN ITALY
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 38, anno: 1995,
pagine: 1729 - 1734
SICI:
0363-6135(1995)38:5<1729:AAVCOH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SINUS ARRHYTHMIA; POWER SPECTRUM ANALYSIS; HEMODYNAMIC REGULATION;
Keywords:
R-R INTERVAL; SPECTRAL POWER; PROPRANOLOL; ATROPINE; MEAN ARTERIAL PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Perlini et al., "AUTONOMIC AND VENTILATORY COMPONENTS OF HEART-RATE AND BLOOD-PRESSUREVARIABILITY IN FREELY BEHAVING RATS", American journal of physiology. Heart and circulatory physiology, 38(5), 1995, pp. 1729-1734

Abstract

The relative role of parasympathetic, sympathetic, and ventilatory influences in the genesis of blood pressure and R-R interval variabilityis controversial. In 13 freely behaving WKY rats instrumented with venous and arterial catheters and chest electrodes, mean arterial pressure (MAP, mmHg), R-R interval (ms), and respiratory fluctuations were monitored for 90 min in the control condition and after intravenous atropine (0.75 mg/kg) and/or propranolol (1 mg/kg). Spectral power (pw) in the 0.25- to 0.75-Hz (midfrequency, MF) and the 0.75- to 3.0-Hz (high-frequency, HF, respiratory-synchronous) bands was computed in sequences of 400 heartbeats by use of a combined autoregressive analysis. Atropine reduced but did not abolish HF R-R interval pw (from 1.73 +/- 0.50 to 0.39 +/- 0.27 ms(2), P < 0.01) and halved HF MAP pw (from 0.41 /- 0.30 to 0.21 +/- 0.12 mmHg(2), P < 0.05), whereas propranolol did not affect HF pw of the R-R interval or MAP. Propranolol also failed to significantly modify MF R-R interval pw (from 0.48 +/- 0.44 to 0.40 /- 0.34 ms(2), P = NS) or MF MAP pw (from 0.54 +/- 0.39 to 0.42 +/- 0.20 mmHg(2), P = NS), whereas atropine virtually abolished MF R-R interval pw (from 0.48 +/- 0.44 to 0.01 +/- 0.01 ms(2), P < 0.01) and alsosignificantly reduced MF MAP pw (from 0.54 +/- 0.39 to 0.33 +/- 0.24 mmHg(2), P < 0.01). The effects of combined blockade were similar to those of atropine alone. It is concluded that, in the unanesthetized rat, efferent vagal influences are responsible for a large fraction of HF R-R interval power, but a sizable amount of such fluctuations persists after atropine and has a ventilatory, rather than an efferent vagal, origin. Vagal influences also contribute to HF MAP power. Vagal (butnot sympathetic) influences are important determinants of NIF R-R interval fluctuations and also contribute significantly to MF MAP fluctuations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:35:33