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Titolo:
THE GROWTH OF HUMAN HIV-1-INFECTED U937 CELLS IN IMMUNE-DEPRIVED MICE
Autore:
CHERNUKHIN IV; CHEPURNOV AA; GAIDUL KV;
Indirizzi:
RUSSIAN ACAD MED SCI,TIMAKOV ST R152 NOVOSIBIRSK 630117 RUSSIA INST MOLEC BIOL KOLTSOV 633159 RUSSIA
Titolo Testata:
Biomedicine & pharmacotherapy
fascicolo: 7-8, volume: 49, anno: 1995,
pagine: 358 - 363
SICI:
0753-3322(1995)49:7-8<358:TGOHHU>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; DIFFERENTIATION; PATHOGENESIS; REPLICATION; MACROPHAGES; EXPRESSION; INTERFERON; LINE; AIDS;
Keywords:
ANIMAL MODEL; U937 CELLS; CHRONICALLY INFECTED CELLS IMMUNE DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
I.V. Chernukhin et al., "THE GROWTH OF HUMAN HIV-1-INFECTED U937 CELLS IN IMMUNE-DEPRIVED MICE", Biomedicine & pharmacotherapy, 49(7-8), 1995, pp. 358-363

Abstract

We report in vivo growth of human promonocytic cells infected with HIV-1 presented in new mouse model. Cloned U937 cells chronically infected with HIV-1 were grafted in (CBAC57B1/6)F1 mice deprived of immunity by thymectomia and total body irradiation with subsequent marrow reconstitution. Nine weeks after cell inoculation, HIV-l-positive cells were found only in mice that received an additional single dose of cyclophosphamide (100 mg/kg bw) prior to transplantation, whereas, in micewithout further immune deprivation, the complete elimination of cellsbearing viral antigen occured already on the seventh day after transplantation. The approach described may be suitable for in vivo development of antiviral drugs against latent infection in macrophage-like cells which represents a serious problem in therapy of AIDS in humans.

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Documento generato il 27/09/20 alle ore 01:01:38